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1p4t

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[[Image:1p4t.jpg|left|200px]]
[[Image:1p4t.jpg|left|200px]]
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{{Structure
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|PDB= 1p4t |SIZE=350|CAPTION= <scene name='initialview01'>1p4t</scene>, resolution 2.55&Aring;
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The line below this paragraph, containing "STRUCTURE_1p4t", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CXE:PENTAETHYLENE+GLYCOL+MONODECYL+ETHER'>CXE</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|GENE= nspa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=487 Neisseria meningitidis])
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|DOMAIN=
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{{STRUCTURE_1p4t| PDB=1p4t | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p4t OCA], [http://www.ebi.ac.uk/pdbsum/1p4t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p4t RCSB]</span>
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'''Crystal structure of Neisserial surface protein A (NspA)'''
'''Crystal structure of Neisserial surface protein A (NspA)'''
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[[Category: Tommassen, J.]]
[[Category: Tommassen, J.]]
[[Category: Vandeputte-Rutten, L.]]
[[Category: Vandeputte-Rutten, L.]]
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[[Category: beta barrel]]
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[[Category: Beta barrel]]
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[[Category: outer membrane protein]]
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[[Category: Outer membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:41:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:54:49 2008''
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Revision as of 01:41, 3 May 2008

Image:1p4t.jpg

Template:STRUCTURE 1p4t

Crystal structure of Neisserial surface protein A (NspA)


Overview

The neisserial surface protein A (NspA) from Neisseria meningitidis is a promising vaccine candidate because it is highly conserved among meningococcal strains and induces bactericidal antibodies. NspA is a homolog of the Opa proteins, which mediate adhesion to host cells. Here, we present the crystal structure of NspA, determined to 2.55-A resolution. NspA forms an eight-stranded antiparallel beta-barrel. The four loops at the extracellular side of the NspA molecule form a long cleft, which contains mainly hydrophobic residues and harbors a detergent molecule, suggesting that the protein might function in the binding of hydrophobic ligands, such as lipids. In addition, the structure provides a starting point for structure-based vaccine design.

About this Structure

1P4T is a Single protein structure of sequence from Neisseria meningitidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of Neisserial surface protein A (NspA), a conserved outer membrane protein with vaccine potential., Vandeputte-Rutten L, Bos MP, Tommassen J, Gros P, J Biol Chem. 2003 Jul 4;278(27):24825-30. Epub 2003 Apr 26. PMID:12716881 Page seeded by OCA on Sat May 3 04:41:15 2008

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