1p53

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[[Image:1p53.gif|left|200px]]
[[Image:1p53.gif|left|200px]]
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{{Structure
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|PDB= 1p53 |SIZE=350|CAPTION= <scene name='initialview01'>1p53</scene>, resolution 3.06&Aring;
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The line below this paragraph, containing "STRUCTURE_1p53", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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|GENE= ICAM1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1p53| PDB=1p53 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p53 OCA], [http://www.ebi.ac.uk/pdbsum/1p53 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p53 RCSB]</span>
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'''The Crystal Structure of ICAM-1 D3-D5 fragment'''
'''The Crystal Structure of ICAM-1 D3-D5 fragment'''
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[[Category: Yang, Y.]]
[[Category: Yang, Y.]]
[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
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[[Category: beta-sheet]]
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[[Category: Beta-sheet]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: igsf domain]]
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[[Category: Igsf domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:41:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:54:57 2008''
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Revision as of 01:41, 3 May 2008

Image:1p53.gif

Template:STRUCTURE 1p53

The Crystal Structure of ICAM-1 D3-D5 fragment


Contents

Overview

We have determined the 3.0 A crystal structure of the three C-terminal domains 3-5 (D3-D5) of ICAM-1. Combined with the previously known N-terminal two-domain structure (D1D2), a model of an entire ICAM-1 extracellular fragment has been constructed. This model should represent a general architecture of other ICAM family members, particularly ICAM-3 and ICAM-5. The observed intimate dimerization interaction at D4 and a stiff D4-D5 stem-like architecture provide a good structural explanation for the existence of preformed ICAM-1 cis dimers on the cell membrane. Together with another dimerization interface at D1, a band-like one-dimensional linear cluster of ICAM-1 on an antigen-presenting cell (APC) surface can be envisioned, which might explain the formation of an immunological synapse between an activated T cell and APC which is critical for T cell receptor signaling.

Disease

Known disease associated with this structure: Malaria, cerebral, susceptibility to OMIM:[147840]

About this Structure

1P53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for dimerization of ICAM-1 on the cell surface., Yang Y, Jun CD, Liu JH, Zhang R, Joachimiak A, Springer TA, Wang JH, Mol Cell. 2004 Apr 23;14(2):269-76. PMID:15099525 Page seeded by OCA on Sat May 3 04:41:50 2008

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