1p5d

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[[Image:1p5d.jpg|left|200px]]
[[Image:1p5d.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1p5d |SIZE=350|CAPTION= <scene name='initialview01'>1p5d</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1p5d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=G1P:ALPHA-D-GLUCOSE-1-PHOSPHATE'>G1P</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphomannomutase Phosphomannomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.2.8 5.4.2.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ALGC OR PA5322 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa])
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-->
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|DOMAIN=
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{{STRUCTURE_1p5d| PDB=1p5d | SCENE= }}
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|RELATEDENTRY=[[1k35|1K35]], [[1k2y|1K2Y]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p5d OCA], [http://www.ebi.ac.uk/pdbsum/1p5d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p5d RCSB]</span>
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}}
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'''Enzyme-ligand complex of P. aeruginosa PMM/PGM'''
'''Enzyme-ligand complex of P. aeruginosa PMM/PGM'''
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[[Category: Regni, C.]]
[[Category: Regni, C.]]
[[Category: Tipton, P A.]]
[[Category: Tipton, P A.]]
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[[Category: alpha/beta protein]]
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[[Category: Alpha/beta protein]]
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[[Category: enzyme-ligand complex]]
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[[Category: Enzyme-ligand complex]]
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[[Category: enzyme-metal complex]]
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[[Category: Enzyme-metal complex]]
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[[Category: phosphohexomutase]]
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[[Category: Phosphohexomutase]]
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[[Category: phosphoserine]]
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[[Category: Phosphoserine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:42:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:06 2008''
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Revision as of 01:42, 3 May 2008

Image:1p5d.jpg

Template:STRUCTURE 1p5d

Enzyme-ligand complex of P. aeruginosa PMM/PGM


Overview

Enzyme-substrate complexes of phosphomannomutase/phosphoglucomutase (PMM/PGM) reveal the structural basis of the enzyme's ability to use four different substrates in catalysis. High-resolution structures with glucose 1-phosphate, glucose 6-phosphate, mannose 1-phosphate, and mannose 6-phosphate show that the position of the phosphate group of each substrate is held constant by a conserved network of hydrogen bonds. This produces two distinct, and mutually exclusive, binding orientations for the sugar rings of the 1-phospho and 6-phospho sugars. Specific binding of both orientations is accomplished by key contacts with the O3 and O4 hydroxyls of the sugar, which must occupy equatorial positions. Dual recognition of glucose and mannose phosphosugars uses a combination of specific protein contacts and nonspecific solvent contacts. The ability of PMM/PGM to accommodate these four diverse substrates in a single active site is consistent with its highly reversible phosphoryl transfer reaction and allows it to function in multiple biosynthetic pathways in P. aeruginosa.

About this Structure

1P5D is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Structural basis of diverse substrate recognition by the enzyme PMM/PGM from P. aeruginosa., Regni C, Naught L, Tipton PA, Beamer LJ, Structure. 2004 Jan;12(1):55-63. PMID:14725765 Page seeded by OCA on Sat May 3 04:42:22 2008

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