1p5r
From Proteopedia
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| - | + | {{STRUCTURE_1p5r| PDB=1p5r | SCENE= }} | |
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'''Formyl-CoA Transferase in complex with Coenzyme A''' | '''Formyl-CoA Transferase in complex with Coenzyme A''' | ||
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[[Category: Ricagno, S.]] | [[Category: Ricagno, S.]] | ||
[[Category: Richards, N.]] | [[Category: Richards, N.]] | ||
| - | [[Category: | + | [[Category: Caib-baif family]] |
| - | [[Category: | + | [[Category: Coa complex]] |
| - | [[Category: | + | [[Category: Coa-transferase]] |
| - | [[Category: | + | [[Category: Intertwined]] |
| - | [[Category: | + | [[Category: Knotted fold]] |
| - | [[Category: | + | [[Category: Oxalate]] |
| - | [[Category: | + | [[Category: Oxalate degradation]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:43:06 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:43, 3 May 2008
Formyl-CoA Transferase in complex with Coenzyme A
Overview
Formyl-CoA transferase catalyses transfer of CoA from formate to oxalate in the first step of oxalate degradation by Oxalobacter formigenes, a bacterium present in the intestinal flora which is implicated in oxalate catabolism in mammals. Formyl-CoA transferase is a member of a family of CoA-transferases for which no structural information is available. We now report the three-dimensional structure of O.formigenes formyl-CoA transferase, which reveals a novel fold and a very striking assembly of the homodimer. The subunit is composed of a large and a small domain where residues from both the N- and C-termini of the subunit are part of the large domain. The linkers between the domains give the subunit a circular shape with a hole in the middle. The enzyme monomers are tightly interacting and are interlocked. This fold requires drastic rearrangement of approximately 75 residues at the C-terminus for formation of the dimer. The structure of a complex of formyl-CoA transferase with CoA is also reported and sets the scene for a mechanistic understanding of enzymes of this family of CoA-transferases.
About this Structure
1P5R is a Single protein structure of sequence from Oxalobacter formigenes. Full crystallographic information is available from OCA.
Reference
Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer., Ricagno S, Jonsson S, Richards N, Lindqvist Y, EMBO J. 2003 Jul 1;22(13):3210-9. PMID:12839984 Page seeded by OCA on Sat May 3 04:43:06 2008
