1p6o

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[[Image:1p6o.gif|left|200px]]
[[Image:1p6o.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1p6o |SIZE=350|CAPTION= <scene name='initialview01'>1p6o</scene>, resolution 1.14&Aring;
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The line below this paragraph, containing "STRUCTURE_1p6o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HPY:4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE'>HPY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cytosine_deaminase Cytosine deaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.4.1 3.5.4.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FCY1 OR YPR062W OR YP9499.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1p6o| PDB=1p6o | SCENE= }}
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|RELATEDENTRY=[[1ox7|1OX7]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p6o OCA], [http://www.ebi.ac.uk/pdbsum/1p6o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p6o RCSB]</span>
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}}
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'''The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.'''
'''The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.'''
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[[Category: Ireton, G C.]]
[[Category: Ireton, G C.]]
[[Category: Stoddard, B L.]]
[[Category: Stoddard, B L.]]
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[[Category: cytosine deaminase]]
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[[Category: Cytosine deaminase]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: inhibitor bound]]
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[[Category: Inhibitor bound]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:45:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:36 2008''
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Revision as of 01:45, 3 May 2008

Image:1p6o.gif

Template:STRUCTURE 1p6o

The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.


Overview

Cytosine deaminase (CD) catalyzes the deamination of cytosine and is only present in prokaryotes and fungi, where it is a member of the pyrimidine salvage pathway. The enzyme is of interest both for antimicrobial drug design and gene therapy applications against tumors. The structure of Saccharomyces cerevisiae CD has been determined in the presence and absence of a mechanism-based inhibitor, at 1.14 and 1.43 A resolution, respectively. The enzyme forms an alpha/beta fold similar to bacterial cytidine deaminase, but with no similarity to the alpha/beta barrel fold used by bacterial cytosine deaminase or mammalian adenosine deaminase. The structures observed for bacterial, fungal, and mammalian nucleic acid deaminases represent an example of the parallel evolution of two unique protein folds to carry out the same reaction on a diverse array of substrates.

About this Structure

1P6O is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy., Ireton GC, Black ME, Stoddard BL, Structure. 2003 Aug;11(8):961-72. PMID:12906827 Page seeded by OCA on Sat May 3 04:45:12 2008

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OCA

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