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5tbm

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==Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex==
==Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex==
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<StructureSection load='5tbm' size='340' side='right' caption='[[5tbm]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='5tbm' size='340' side='right'caption='[[5tbm]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5tbm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TBM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5tbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TBM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5TBM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=79A:3-{[(1S)-2,2-DIFLUORO-1-HYDROXY-7-(METHYLSULFONYL)-2,3-DIHYDRO-1H-INDEN-4-YL]OXY}-5-FLUOROBENZONITRILE'>79A</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=79A:3-{[(1S)-2,2-DIFLUORO-1-HYDROXY-7-(METHYLSULFONYL)-2,3-DIHYDRO-1H-INDEN-4-YL]OXY}-5-FLUOROBENZONITRILE'>79A</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbm OCA], [http://pdbe.org/5tbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tbm RCSB], [http://www.ebi.ac.uk/pdbsum/5tbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbm ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EPAS1, BHLHE73, HIF2A, MOP2, PASD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), ARNT, BHLHE2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5tbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tbm OCA], [http://pdbe.org/5tbm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tbm RCSB], [http://www.ebi.ac.uk/pdbsum/5tbm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tbm ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Du, X]]
[[Category: Du, X]]
[[Category: Hif2 inhibitor hif2 ligand pas-b hypoxia inducible factor 2 epas1]]
[[Category: Hif2 inhibitor hif2 ligand pas-b hypoxia inducible factor 2 epas1]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 11:28, 16 September 2020

Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex

PDB ID 5tbm

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