2m4h

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==Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein==
==Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein==
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<StructureSection load='2m4h' size='340' side='right' caption='[[2m4h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2m4h' size='340' side='right'caption='[[2m4h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2m4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Fcv Fcv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M4H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2m4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fcv Fcv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M4H FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF1, VPg ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11981 FCV])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ORF1, VPg ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11981 FCV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m4h OCA], [http://pdbe.org/2m4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m4h RCSB], [http://www.ebi.ac.uk/pdbsum/2m4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2m4h ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m4h OCA], [https://pdbe.org/2m4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m4h RCSB], [https://www.ebi.ac.uk/pdbsum/2m4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m4h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/POLG_FCVF9 POLG_FCVF9]] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity). Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
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[[https://www.uniprot.org/uniprot/POLG_FCVF9 POLG_FCVF9]] NTPase presumably plays a role in replication. Despite having similarities with helicases, does not seem to display any helicase activity (By similarity). Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation (By similarity). Protease-polymerase p76 processes the polyprotein: Pro-Pol is first released by autocleavage, then all other proteins are cleaved. Cleaves host translation initiation factor eIF4G1 and eIF4G2 thereby inducing a shutdown of host protein synthesis. This shutdown may not prevent viral mRNA from being translated since viral Vpg replaces the cap. May cleave host polyadenylate-binding protein thereby inhibiting cellular translation. It is also a RNA-directed RNA polymerase which replicates genomic and antigenomic viral RNA by recognizing specific signals. Transcribes also a subgenomic mRNA by initiating RNA synthesis internally on antigenomic RNA. This sgRNA encodes for structural proteins. Catalyzes the covalent attachment VPg with viral RNAs (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Fcv]]
[[Category: Fcv]]
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[[Category: Large Structures]]
[[Category: Birtley, J R]]
[[Category: Birtley, J R]]
[[Category: Curry, S]]
[[Category: Curry, S]]

Revision as of 10:59, 19 May 2021

Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein

PDB ID 2m4h

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