2j9k
From Proteopedia
(New page: 200px<br /> <applet load="2j9k" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j9k, resolution 1.20Å" /> '''ATOMIC-RESOLUTION C...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2J9K is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]] with SO4, ACT, ACE, NH2 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J9K OCA]]. | + | 2J9K is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]] with SO4, ACT, ACE, NH2 and GOL as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J9K OCA]]. |
==Reference== | ==Reference== | ||
Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors., Johnson EC, Malito E, Shen Y, Pentelute B, Rich D, Florian J, Tang WJ, Kent SB, J Mol Biol. 2007 Oct 26;373(3):573-86. Epub 2007 Aug 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17869270 17869270] | Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors., Johnson EC, Malito E, Shen Y, Pentelute B, Rich D, Florian J, Tang WJ, Kent SB, J Mol Biol. 2007 Oct 26;373(3):573-86. Epub 2007 Aug 2. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17869270 17869270] | ||
| + | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Johnson, E.C.B.]] | [[Category: Johnson, E.C.B.]] | ||
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[[Category: rna-directed dna polymerase]] | [[Category: rna-directed dna polymerase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:06:33 2007'' |
Revision as of 09:01, 30 October 2007
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ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE COMPLEXED WITH INHIBITOR MVT-101
Overview
The human immunodeficiency virus 1 (HIV-1) protease (PR) is an aspartyl, protease essential for HIV-1 viral infectivity. HIV-1 PR has one catalytic, site formed by the homodimeric enzyme. We chemically synthesized fully, active HIV-1 PR using modern ligation methods. When complexed with the, classic substrate-derived inhibitors JG-365 and MVT-101, the synthetic, HIV-1 PR formed crystals that diffracted to 1.04- and 1.2-A resolution, respectively. These atomic-resolution structures revealed additional, structural details of the HIV-1 PR's interactions with its active site, ligands. Heptapeptide inhibitor JG-365, which has a hydroxyethylamine, moiety in place of the scissile bond, binds in two equivalent antiparallel, orientations within the catalytic groove, whereas the reduced isostere, ... [(full description)]
About this Structure
2J9K is a [Protein complex] structure of sequences from [Human immunodeficiency virus 1] with SO4, ACT, ACE, NH2 and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Insights from Atomic-Resolution X-Ray Structures of Chemically Synthesized HIV-1 Protease in Complex with Inhibitors., Johnson EC, Malito E, Shen Y, Pentelute B, Rich D, Florian J, Tang WJ, Kent SB, J Mol Biol. 2007 Oct 26;373(3):573-86. Epub 2007 Aug 2. PMID:17869270
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