1p7h

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[[Image:1p7h.gif|left|200px]]
[[Image:1p7h.gif|left|200px]]
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{{Structure
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|PDB= 1p7h |SIZE=350|CAPTION= <scene name='initialview01'>1p7h</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1p7h", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NFATC2 OR NFAT1 OR NFATP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1p7h| PDB=1p7h | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p7h OCA], [http://www.ebi.ac.uk/pdbsum/1p7h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p7h RCSB]</span>
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'''Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element'''
'''Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element'''
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[[Category: Koenig, K D.von.]]
[[Category: Koenig, K D.von.]]
[[Category: Stroud, J C.]]
[[Category: Stroud, J C.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: dna binding protein]]
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[[Category: Dna binding protein]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:46:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:56 2008''
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Revision as of 01:46, 3 May 2008

Image:1p7h.gif

Template:STRUCTURE 1p7h

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kB element


Overview

DNA binding by NFAT1 as a dimer has been implicated in the activation of host and viral genes. Here we report a crystal structure of NFAT1 bound cooperatively as a dimer to the highly conserved kappa B site from the human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR). This structure reveals a new mode of dimerization and protein-DNA recognition by the Rel homology region (RHR) of NFAT1. The two NFAT1 monomers form a complete circle around the kappa B DNA through protein-protein interactions mediated by both their N- and C-terminal subdomains. The major dimer interface, formed by the C-terminal domain, is asymmetric and substantially different from the symmetric dimer interface seen in other Rel family proteins. Comparison to other NFAT structures, including NFAT5 and the NFAT1-Fos-Jun-ARRE2 complex, reveals that NFAT1 adopts different conformations and its protein surfaces mediate distinct protein-protein interactions in the context of different DNA sites.

About this Structure

1P7H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of NFAT1 bound as a dimer to the HIV-1 LTR kappa B element., Giffin MJ, Stroud JC, Bates DL, von Koenig KD, Hardin J, Chen L, Nat Struct Biol. 2003 Oct;10(10):800-6. Epub 2003 Aug 31. PMID:12949493 Page seeded by OCA on Sat May 3 04:46:49 2008

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