5lyo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the zymogen matriptase catalytic domain== | |
| - | + | <StructureSection load='5lyo' size='340' side='right' caption='[[5lyo]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5lyo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LYO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matriptase Matriptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.109 3.4.21.109] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lyo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyo OCA], [http://pdbe.org/5lyo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lyo RCSB], [http://www.ebi.ac.uk/pdbsum/5lyo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyo ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Matriptase]] | ||
[[Category: Hong, Z]] | [[Category: Hong, Z]] | ||
| + | [[Category: Jensen, J K]] | ||
| + | [[Category: Enzyme inhibitor]] | ||
| + | [[Category: Hydrolase-inhibitor complex]] | ||
| + | [[Category: Serine protease]] | ||
| + | [[Category: Zymogen]] | ||
Revision as of 07:12, 25 October 2017
Crystal structure of the zymogen matriptase catalytic domain
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