1p9h
From Proteopedia
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'''CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA''' | '''CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA''' | ||
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[[Category: Nummelin, H.]] | [[Category: Nummelin, H.]] | ||
[[Category: Skurnik, M.]] | [[Category: Skurnik, M.]] | ||
| - | [[Category: | + | [[Category: Collagen-binding]] |
| - | [[Category: | + | [[Category: Left-handed beta-roll]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:51:02 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:51, 3 May 2008
CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA
Overview
The crystal structure of the recombinant collagen-binding domain of Yersinia adhesin YadA from Yersinia enterocolitica serotype O:3 was solved at 1.55 A resolution. The trimeric structure is composed of head and neck regions, and the collagen binding head region is a novel nine-coiled left-handed parallel beta-roll. Before the beta-roll, the polypeptide loops from one monomer to the rest, and after the beta-roll the neck region does the same, making the transition from the globular head region to the narrower stalk domain. This creates an intrinsically stable 'lock nut' structure. The trimeric form of YadA is required for collagen binding, and mutagenesis of its surface residues allowed identification of a putative collagen-binding surface. Furthermore, a new structure-sequence motif for YadA beta-roll was used to identify putative YadA-head-like domains in a variety of human and plant pathogens. Such domains may therefore be a common bacterial strategy for avoiding host response.
About this Structure
1P9H is a Single protein structure of sequence from Yersinia enterocolitica. Full crystallographic information is available from OCA.
Reference
The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll., Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A, EMBO J. 2004 Feb 25;23(4):701-11. Epub 2004 Feb 5. PMID:14765110 Page seeded by OCA on Sat May 3 04:51:02 2008
