1p9o

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[[Image:1p9o.jpg|left|200px]]
[[Image:1p9o.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1p9o |SIZE=350|CAPTION= <scene name='initialview01'>1p9o</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1p9o", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphopantothenate--cysteine_ligase Phosphopantothenate--cysteine ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.5 6.3.2.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= coaB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1p9o| PDB=1p9o | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9o OCA], [http://www.ebi.ac.uk/pdbsum/1p9o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p9o RCSB]</span>
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}}
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'''Crystal Structure of Phosphopantothenoylcysteine Synthetase'''
'''Crystal Structure of Phosphopantothenoylcysteine Synthetase'''
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[[Category: Manoj, N.]]
[[Category: Manoj, N.]]
[[Category: Strauss, E.]]
[[Category: Strauss, E.]]
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[[Category: synthetase]]
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[[Category: Synthetase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:51:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:53 2008''
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Revision as of 01:51, 3 May 2008

Image:1p9o.jpg

Template:STRUCTURE 1p9o

Crystal Structure of Phosphopantothenoylcysteine Synthetase


Overview

The structure of human phosphopantothenoylcysteine (PPC) synthetase was determined at 2.3 A resolution. PPC synthetase is a dimer with identical monomers. Some features of the monomer fold resemble a group of NAD-dependent enzymes, while other features resemble the ribokinase fold. The ATP, phosphopantothenate, and cysteine binding sites were deduced from modeling studies. Highly conserved ATP binding residues include Gly43, Ser61, Gly63, Gly66, Phe230, and Asn258. Highly conserved phosphopantothenate binding residues include Asn59, Ala179, Ala180, and Asp183 from one monomer and Arg55' from the adjacent monomer. The structure predicts a ping pong mechanism with initial formation of an acyladenylate intermediate, followed by release of pyrophosphate and attack by cysteine to form the final products PPC and AMP.

About this Structure

1P9O is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution., Manoj N, Strauss E, Begley TP, Ealick SE, Structure. 2003 Aug;11(8):927-36. PMID:12906824 Page seeded by OCA on Sat May 3 04:51:38 2008

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