1pah

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[[Image:1pah.gif|left|200px]]
[[Image:1pah.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pah |SIZE=350|CAPTION= <scene name='initialview01'>1pah</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1pah", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=NUL:Fe+Coordinating+Residues'>NUL</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1pah| PDB=1pah | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pah OCA], [http://www.ebi.ac.uk/pdbsum/1pah PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pah RCSB]</span>
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}}
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'''HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424'''
'''HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424'''
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[[Category: Erlandsen, H.]]
[[Category: Erlandsen, H.]]
[[Category: Stevens, R C.]]
[[Category: Stevens, R C.]]
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[[Category: hydroxylase]]
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[[Category: Hydroxylase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: phenylalanine]]
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[[Category: Phenylalanine]]
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[[Category: phenylketonuria]]
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[[Category: Phenylketonuria]]
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[[Category: pku]]
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[[Category: Pku]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:52:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:57:08 2008''
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Revision as of 01:53, 3 May 2008

Image:1pah.gif

Template:STRUCTURE 1pah

HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424


Overview

The 2.0 A crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals a fold similar to that of tyrosine hydroxylase. It provides the first structural view of where mutations occur and a rationale to explain molecular mechanisms of the enzymatic phenotypes in the autosomal recessive disorder phenylketoneuria.

About this Structure

1PAH is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 1PAH with [Phenylalanine Hydroxylase]. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria., Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC, Nat Struct Biol. 1997 Dec;4(12):995-1000. PMID:9406548 Page seeded by OCA on Sat May 3 04:52:59 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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