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User:Wally Novak/Sandbox Hicks
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== Structural Highlights == | == Structural Highlights == | ||
| - | <scene name='74/744126/Pcna_monomer_helixfront_2/1'> The PCNA monomers </scene> consist of 258 residues each and are a mass of 28.916 kDa. Each monomer contributes two domains to the trimeric ring. These domains possess anti-parallel beta sheets (blue) which approach each other on one end, but are separated by two alpha helices at the other (red), creating a 45 degree wedge in the sheets with alpha helices at the blunt end. The domains are connected by an extended beta sheet. This creates a <scene name='74/744126/6_fold_symmetry/1'> six-fold symmetry within the trimeric ring </scene> and it also creates a β-α-β-β-β motif going around the ring. <ref>8001157</ref> | + | <scene name='74/744126/Pcna_monomer_helixfront_2/1'> The PCNA monomers </scene> consist of 258 residues each and are a mass of 28.916 kDa. Each monomer contributes two domains to the trimeric ring. These domains possess anti-parallel beta sheets (blue) which approach each other on one end, but are separated by two alpha helices at the other (red), creating a 45 degree wedge in the sheets with alpha helices at the blunt end. The domains are connected by an extended beta sheet. This creates a <scene name='74/744126/6_fold_symmetry/1'> six-fold symmetry within the trimeric ring </scene> and it also creates a β-α-β-β-β motif going around the ring. <ref>PMID:8001157</ref> |
== Interaction with DNA == | == Interaction with DNA == | ||
| + | Since PCNA is a sliding clamp protein, it must be able to loosely interact with DNA. | ||
| + | <ref>doi:10.1006</ref> | ||
| + | |||
| + | PCNA also has many <scene name='74/744126/Acidic_residues_pcna/1'>Text To Be Displayed</scene> | ||
| - | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 10:52, 11 October 2016
Proliferating Cell Nuclear Antigen
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References
- ↑ PMCID:PMC53402
- ↑ Lee SH, Kwong AD, Pan ZQ, Hurwitz J. Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta. J Biol Chem. 1991 Jan 5;266(1):594-602. PMID:1670772
- ↑ Krishna TS, Kong XP, Gary S, Burgers PM, Kuriyan J. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell. 1994 Dec 30;79(7):1233-43. PMID:8001157
- ↑ doi: https://dx.doi.org/10.1006
