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1pbw
From Proteopedia
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[[Image:1pbw.gif|left|200px]] | [[Image:1pbw.gif|left|200px]] | ||
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'''STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN''' | '''STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN''' | ||
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[[Category: Harrison, S C.]] | [[Category: Harrison, S C.]] | ||
[[Category: Musacchio, A.]] | [[Category: Musacchio, A.]] | ||
| - | [[Category: | + | [[Category: Cdc42]] |
| - | [[Category: | + | [[Category: Gap]] |
| - | [[Category: | + | [[Category: Phosphoinositide 3-kinase]] |
| - | [[Category: | + | [[Category: Phosphotransferase]] |
| - | [[Category: | + | [[Category: Sh2 domain]] |
| - | [[Category: | + | [[Category: Sh3 domain]] |
| - | [[Category: | + | [[Category: Signal transduction]] |
| - | [[Category: | + | [[Category: Tpase activating protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:55:08 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 01:55, 3 May 2008
STRUCTURE OF BCR-HOMOLOGY (BH) DOMAIN
Overview
Proteins such as the product of the break-point cluster region, chimaerin, and the Src homology 3-binding protein 3BP1, are GTPase activating proteins (GAPs) for members of the Rho subfamily of small GTP-binding proteins (G proteins or GTPases). A 200-residue region, named the breakpoint cluster region-homology (BH) domain, is responsible for the GAP activity. We describe here the crystal structure of the BH domain from the p85 subunit of phosphatidylinositol 3-kinase at 2.0 A resolution. The domain is composed of seven helices, having a previously unobserved arrangement. A core of four helices contains most residues that are conserved in the BH family. Their packing suggests the location of a G-protein binding site. This structure of a GAP-like domain for small GTP-binding proteins provides a framework for analyzing the function of this class of molecules.
About this Structure
1PBW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit., Musacchio A, Cantley LC, Harrison SC, Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14373-8. PMID:8962058 Page seeded by OCA on Sat May 3 04:55:08 2008
