1pd3
From Proteopedia
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'''Influenza A NEP M1-binding domain''' | '''Influenza A NEP M1-binding domain''' | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Baudin, F.]] | [[Category: Baudin, F.]] | ||
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| - | [[Category: | + | [[Category: Nep/ns2]] |
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Revision as of 01:57, 3 May 2008
Influenza A NEP M1-binding domain
Overview
During influenza virus infection, viral ribonucleoproteins (vRNPs) are replicated in the nucleus and must be exported to the cytoplasm before assembling into mature viral particles. Nuclear export is mediated by the cellular protein Crm1 and putatively by the viral protein NEP/NS2. Proteolytic cleavage of NEP defines an N-terminal domain which mediates RanGTP-dependent binding to Crm1 and a C-terminal domain which binds to the viral matrix protein M1. The 2.6 A crystal structure of the C-terminal domain reveals an amphipathic helical hairpin which dimerizes as a four-helix bundle. The NEP-M1 interaction involves two critical epitopes: an exposed tryptophan (Trp78) surrounded by a cluster of glutamate residues on NEP, and the basic nuclear localization signal (NLS) of M1. Implications for vRNP export are discussed.
About this Structure
1PD3 is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.
Reference
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2)., Akarsu H, Burmeister WP, Petosa C, Petit I, Muller CW, Ruigrok RW, Baudin F, EMBO J. 2003 Sep 15;22(18):4646-55. PMID:12970177 Page seeded by OCA on Sat May 3 04:57:15 2008
