This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4len
From Proteopedia
| Line 1: | Line 1: | ||
==CTX-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid== | ==CTX-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid== | ||
| - | <StructureSection load='4len' size='340' side='right' caption='[[4len]], [[Resolution|resolution]] 1.50Å' scene=''> | + | <StructureSection load='4len' size='340' side='right'caption='[[4len]], [[Resolution|resolution]] 1.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4len]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LEN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4len]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LEN FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GK:(2E)-3-[2-(DIHYDROXYBORANYL)-1-BENZOTHIOPHEN-3-YL]PROP-2-ENOIC+ACID'>2GK</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2GK:(2E)-3-[2-(DIHYDROXYBORANYL)-1-BENZOTHIOPHEN-3-YL]PROP-2-ENOIC+ACID'>2GK</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaCTX-M-9, blaCTX-M-9a, blaCTX-M-9a blaCTX-M-9 blaCTX-M-9b, blaCTX-M-9b ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4len FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4len OCA], [http://pdbe.org/4len PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4len RCSB], [http://www.ebi.ac.uk/pdbsum/4len PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4len ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4len FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4len OCA], [http://pdbe.org/4len PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4len RCSB], [http://www.ebi.ac.uk/pdbsum/4len PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4len ProSAT]</span></td></tr> | ||
| Line 24: | Line 25: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bacillus coli migula 1895]] | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Tondi, D]] | [[Category: Tondi, D]] | ||
[[Category: Bacterial resistance]] | [[Category: Bacterial resistance]] | ||
Revision as of 09:12, 3 April 2019
CTX-M-9 in complex with the broad spectrum inhibitor 3-(2- carboxyvinyl)benzo(b)thiophene-2-boronic acid
| |||||||||||
Categories: Bacillus coli migula 1895 | Beta-lactamase | Large Structures | Tondi, D | Bacterial resistance | Beta lactamase | Binding site | Boronic acid | Broad spectrum | Double perturbation cycle analysis | Drug discovery | Enzyme inhibitor | Hydrolase-hydrolase inhibitor complex | Molecular | Structure activity relationship | Structure base drug design | Thermodynamic
