This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5elu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5elu is ON HOLD until Paper Publication
+
==Isoform-specific inhibition of SUMO-dependent protein-protein interactions==
-
 
+
<StructureSection load='5elu' size='340' side='right' caption='[[5elu]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-
Authors: Hughes, D.J., Tiede, C., Hall, N., Tang, A.A.S., Trinh, C.H., Zajac, K., Mandal, U., Howell, G., Edwards, T.A., McPherson, M.J., Tomlinson, D.C., Whitehouse, A.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[5elu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ELU FirstGlance]. <br>
-
Description: Isoform-specific inhibition of SUMO-dependent protein-protein interactions
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5elu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5elu OCA], [http://pdbe.org/5elu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5elu RCSB], [http://www.ebi.ac.uk/pdbsum/5elu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5elu ProSAT]</span></td></tr>
-
[[Category: Whitehouse, A]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN]] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Edwards, T A]]
[[Category: Hall, N]]
[[Category: Hall, N]]
-
[[Category: Trinh, C.H]]
+
[[Category: Howell, G]]
-
[[Category: Tomlinson, D.C]]
+
[[Category: Hughes, D J]]
-
[[Category: Tang, A.A.S]]
+
[[Category: Mandal, U]]
-
[[Category: Edwards, T.A]]
+
[[Category: McPherson, M J]]
-
[[Category: Mcpherson, M.J]]
+
[[Category: Tang, A A.S]]
[[Category: Tiede, C]]
[[Category: Tiede, C]]
-
[[Category: Howell, G]]
+
[[Category: Tomlinson, D C]]
 +
[[Category: Trinh, C H]]
 +
[[Category: Whitehouse, A]]
[[Category: Zajac, K]]
[[Category: Zajac, K]]
-
[[Category: Hughes, D.J]]
+
[[Category: Signaling protein]]
-
[[Category: Mandal, U]]
+
[[Category: Sumoylation]]
 +
[[Category: Ubiquitin]]

Revision as of 03:22, 10 December 2016

Isoform-specific inhibition of SUMO-dependent protein-protein interactions

5elu, resolution 2.35Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5elu"
Personal tools