1pfe

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[[Image:1pfe.gif|left|200px]]
[[Image:1pfe.gif|left|200px]]
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{{Structure
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|PDB= 1pfe |SIZE=350|CAPTION= <scene name='initialview01'>1pfe</scene>, resolution 1.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1pfe", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DSN:D-SERINE'>DSN</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=NCY:N-METHYLCYSTEINE'>NCY</scene>, <scene name='pdbligand=QUI:2-CARBOXYQUINOXALINE'>QUI</scene>, <scene name='pdbligand=SER:SERINE'>SER</scene>
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{{STRUCTURE_1pfe| PDB=1pfe | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pfe OCA], [http://www.ebi.ac.uk/pdbsum/1pfe PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pfe RCSB]</span>
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'''Echinomycin-(gcgtacgc)2 complex'''
'''Echinomycin-(gcgtacgc)2 complex'''
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==About this Structure==
==About this Structure==
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1PFE is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFE OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFE OCA].
==Reference==
==Reference==
Structures of complexes between echinomycin and duplex DNA., Cuesta-Seijo JA, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):442-8. Epub 2005, Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15805599 15805599]
Structures of complexes between echinomycin and duplex DNA., Cuesta-Seijo JA, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):442-8. Epub 2005, Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15805599 15805599]
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[[Category: Protein complex]]
 
[[Category: Cuesta-Seijo, J A.]]
[[Category: Cuesta-Seijo, J A.]]
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[[Category: bisintercalator]]
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[[Category: Bisintercalator]]
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[[Category: duplex dna]]
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[[Category: Duplex dna]]
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[[Category: echinomycin]]
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[[Category: Echinomycin]]
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[[Category: hoogsteen base pairing]]
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[[Category: Hoogsteen base pairing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:01:19 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:58:52 2008''
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Revision as of 02:01, 3 May 2008

Image:1pfe.gif

Template:STRUCTURE 1pfe

Echinomycin-(gcgtacgc)2 complex


Overview

The structure of the bis-intercalation complex of the depsipeptide antibiotic echinomycin with (CGTACG)2 has been redetermined at a higher resolution (1.4 A) and new high-resolution structures (1.1-1.5 A) are reported for the complexes of echinomycin with (GCGTACGC)2 (at both low and high ionic strengths) and (ACGTACGT)2. The structures show the expected Hoogsteen pairing for the base pairs flanking the intercalating chromophores on the outside and Watson-Crick pairing for both base pairs enclosed by the echinomycin. In the octamer complexes but not the hexamer complex, the echinomycin molecule, which would possess a molecular twofold axis were it not for the thioacetal bridge, shows twofold disorder. In all the structures the stacking of the base pairs and chromophores is extended by intermolecular stacking. The structures provide more precise details of the hydrogen bonding and other interactions between the bis-intercalating antibiotics and the duplex DNA than were previously available.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structures of complexes between echinomycin and duplex DNA., Cuesta-Seijo JA, Sheldrick GM, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):442-8. Epub 2005, Mar 24. PMID:15805599 Page seeded by OCA on Sat May 3 05:01:19 2008

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