5h1h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of SLBA, a chimera of SFTI== | |
| + | <StructureSection load='5h1h' size='340' side='right' caption='[[5h1h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5h1h]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H1H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H1H FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5h1i|5h1i]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h1h OCA], [http://pdbe.org/5h1h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h1h RCSB], [http://www.ebi.ac.uk/pdbsum/5h1h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h1h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An orally active and metabolically stable peptide TIBA was successfully engineered as a chimera by fusing an analgesic bradykinin receptor antagonist peptide and the trypsin inhibitory loop of sunflower trypsin inhibitor-1. As a fusion cyclic peptide, the metabolically labile analgesic peptide is protected from degradation by exopeptidases as well as the endopeptidases, and its serum half-life extended from <5 min to >6 h as a chimera. Moreover, the chimera TIBA was also found to be orally active in an animal pain model using a hot plate assay. | ||
| - | + | An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor.,Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam JP J Med Chem. 2017 Jan 12;60(1):504-510. doi: 10.1021/acs.jmedchem.6b01011. Epub, 2016 Dec 15. PMID:27977181<ref>PMID:27977181</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5h1h" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Tam, J P]] | ||
[[Category: Xiao, T]] | [[Category: Xiao, T]] | ||
| - | [[Category: | + | [[Category: Cyclic peptide]] |
| + | [[Category: De novo protein]] | ||
| + | [[Category: Disulphide bond]] | ||
| + | [[Category: Slba]] | ||
| + | [[Category: Sunflower trypsin inhibitor]] | ||
Revision as of 12:57, 19 April 2017
NMR structure of SLBA, a chimera of SFTI
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