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5tc1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==In situ structures of the genome and genome-delivery apparatus in ssRNA bacteriophage MS2== | |
| - | + | <StructureSection load='5tc1' size='340' side='right' caption='[[5tc1]], [[Resolution|resolution]] 3.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tc1]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_ms2 Enterobacteria phage ms2] and [http://en.wikipedia.org/wiki/Enterobacterio_phage_ms2 Enterobacterio phage ms2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TC1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ms2|2ms2]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tc1 OCA], [http://pdbe.org/5tc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5tc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tc1 ProSAT]</span></td></tr> |
| - | [[Category: Dai, X | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CAPSD_BPMS2 CAPSD_BPMS2]] Self-assembles to form the T=3 icosahedral virus shell that protects the viral nucleic acid. Acts as a translational repressor by binding with high specificity to a single stem-loop structure in the genomic RNA that contains the initiation codon of the gene for the viral replicase. Involved in virus assembly through the interaction between a capsid protein dimer and the multiple packaging signals present in the RNA genome.<ref>PMID:16531233</ref> <ref>PMID:18662904</ref> <ref>PMID:26608810</ref> <ref>PMID:8254664</ref> <ref>PMID:9245600</ref> <ref>PMID:9469847</ref> [[http://www.uniprot.org/uniprot/MAT_BPMS2 MAT_BPMS2]] The maturation protein is required for the typical attachment of the phage to the side of the bacterial pili (PubMed:23810697). MP binds to sequences located toward each end of the genome, hence circularizing it (PubMed:26608810). The RNA genome-MP complex is released from the capsid upon host receptor binding (PubMed:23810697). MP enters the cell along with the viral RNA (PubMed:4551992).<ref>PMID:23810697</ref> <ref>PMID:26608810</ref> <ref>PMID:4551992</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Enterobacteria phage ms2]] | ||
| + | [[Category: Enterobacterio phage ms2]] | ||
| + | [[Category: Dai, X H]] | ||
| + | [[Category: Du, Y S]] | ||
| + | [[Category: Lai, M]] | ||
| + | [[Category: Li, Z H]] | ||
[[Category: Shu, S]] | [[Category: Shu, S]] | ||
| - | [[Category: Lai, M]] | ||
| - | [[Category: Zhou, Z.H]] | ||
| - | [[Category: Du, Y.S]] | ||
| - | [[Category: Li, Z.H]] | ||
[[Category: Sun, R]] | [[Category: Sun, R]] | ||
| + | [[Category: Zhou, Z H]] | ||
| + | [[Category: Asymmetric cryoem reconstruction]] | ||
| + | [[Category: Genome-capsid interaction]] | ||
| + | [[Category: Genome-delivery apparatus]] | ||
| + | [[Category: Ssrna genome structure]] | ||
| + | [[Category: Viral protein-rna complex]] | ||
Revision as of 02:19, 11 December 2016
In situ structures of the genome and genome-delivery apparatus in ssRNA bacteriophage MS2
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