5tf2

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'''Unreleased structure'''
 
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The entry 5tf2 is ON HOLD until Nov 18 2017
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==CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN==
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<StructureSection load='5tf2' size='340' side='right' caption='[[5tf2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Walker, J.R., Zhang, Q., Dong, A., Wernimont, A., Li, Y., He, H., Tempel, W., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Chen, Z., Tong, Y., STRUCTURAL GENOMICS CONSORTIUM (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5tf2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TF2 FirstGlance]. <br>
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Description: CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN (CASP target)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tf2 OCA], [http://pdbe.org/5tf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tf2 RCSB], [http://www.ebi.ac.uk/pdbsum/5tf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tf2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PREB_HUMAN PREB_HUMAN]] Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitement of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.[UniProtKB:Q9WTV0][UniProtKB:Q9WUQ2] Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.[UniProtKB:Q9WTV0]
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Chen, Z]]
[[Category: Dong, A]]
[[Category: Dong, A]]
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[[Category: Edwards, A M]]
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[[Category: He, H]]
[[Category: Li, Y]]
[[Category: Li, Y]]
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[[Category: Wernimont, A]]
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[[Category: Structural genomic]]
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[[Category: Walker, J.R]]
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[[Category: Chen, Z]]
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[[Category: Bountra, C]]
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[[Category: Tempel, W]]
[[Category: Tempel, W]]
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[[Category: Arrowsmith, C.H]]
 
[[Category: Tong, Y]]
[[Category: Tong, Y]]
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[[Category: Edwards, A.M]]
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[[Category: Walker, J R]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Wernimont, A]]
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[[Category: He, H]]
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[[Category: Zhang, Q]]
[[Category: Zhang, Q]]
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[[Category: Activator]]
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[[Category: Protein transport]]
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[[Category: Transcription]]
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[[Category: Wd40]]

Revision as of 10:58, 10 December 2016

CRYSTAL STRUCTURE OF THE WD40 DOMAIN OF THE HUMAN PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN

5tf2, resolution 2.80Å

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