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5tke
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Eukaryotic Hydrolase== | |
| - | + | <StructureSection load='5tke' size='340' side='right' caption='[[5tke]], [[Resolution|resolution]] 2.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tke]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TKE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5TKE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5tke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tke OCA], [http://pdbe.org/5tke PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5tke RCSB], [http://www.ebi.ac.uk/pdbsum/5tke PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5tke ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN]] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Jiang, J]] | ||
| + | [[Category: Li, B]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 21:46, 15 March 2017
Crystal Structure of Eukaryotic Hydrolase
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Categories: Jiang, J | Li, B | Hydrolase
