1pjh

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[[Image:1pjh.jpg|left|200px]]
[[Image:1pjh.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1pjh |SIZE=350|CAPTION= <scene name='initialview01'>1pjh</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1pjh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dodecenoyl-CoA_isomerase Dodecenoyl-CoA isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.3.8 5.3.3.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ECI1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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-->
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|DOMAIN=
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{{STRUCTURE_1pjh| PDB=1pjh | SCENE= }}
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|RELATEDENTRY=[[1hno|1HNO]], [[1hnu|1HNU]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjh OCA], [http://www.ebi.ac.uk/pdbsum/1pjh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pjh RCSB]</span>
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}}
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'''Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily'''
'''Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily'''
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[[Category: Mursula, A M.]]
[[Category: Mursula, A M.]]
[[Category: Wierenga, R K.]]
[[Category: Wierenga, R K.]]
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[[Category: beta-beta-alpha spiral fold]]
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[[Category: Beta-beta-alpha spiral fold]]
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[[Category: inter-trimer contact]]
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[[Category: Inter-trimer contact]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:09:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:00:31 2008''
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Revision as of 02:09, 3 May 2008

Image:1pjh.jpg

Template:STRUCTURE 1pjh

Structural studies on delta3-delta2-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily


Overview

Subunits of the enzymes in the crotonase superfamily form tight trimeric disks. In most members of this protein superfamily these disks assemble further into hexamers. Here we report on the 2.1 A structure of a tight hexameric crystal form of the yeast peroxisomal delta(3)-delta(2)-enoyl-CoA isomerase (Eci1p). A comparison of this structure to a previously solved crystal form of Eci1p and other structures of this superfamily shows that there is much variability with respect to the relative distance between the disks and their relative orientations. In particular helices H2 and H9 are involved in the inter-trimer contacts and there are considerable structural differences in these helices in this superfamily. Helices H2 and H9 are near the catalytic cavity and it is postulated that the observed structural variability of these helices, stabilized by the different modes of assembly, has allowed the evolution of the wide range of substrate and catalytic specificity within this enzyme superfamily.

About this Structure

1PJH is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural studies on delta(3)-delta(2)-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase superfamily., Mursula AM, Hiltunen JK, Wierenga RK, FEBS Lett. 2004 Jan 16;557(1-3):81-7. PMID:14741345 Page seeded by OCA on Sat May 3 05:09:13 2008

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