1pjw

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjw OCA], [http://www.ebi.ac.uk/pdbsum/1pjw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pjw RCSB]</span>
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'''Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein'''
'''Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein'''
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[[Category: Wu, C W.]]
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[[Category: E protein]]
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[[Category: epitope mapping]]
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[[Category: Epitope mapping]]
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[[Category: flavivirus]]
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[[Category: Flavivirus]]
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[[Category: jev]]
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[[Category: Jev]]
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[[Category: nmr]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:10:12 2008''
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Revision as of 02:10, 3 May 2008

Image:1pjw.gif

Template:STRUCTURE 1pjw

Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein


Overview

The flavivirus envelope protein is the dominant antigen in eliciting neutralizing antibodies and plays an important role in inducing immunologic responses in the infected host. We have determined the solution structure of the major antigenic domain (domain III) of the Japanese encephalitis virus (JEV) envelope protein. The JEV domain III forms a beta-barrel type structure composed of six antiparallel beta-strands resembling the immunoglobulin constant domain. We have also identified epitopes of the JEV domain III to its neutralizing antibody by chemical shift perturbation measurements. Site-directed mutagenesis experiments are performed to confirm the NMR results. Our study provides a structural basis for understanding the mechanism of immunologic protection and for rational design of vaccines effective against flaviviruses.

About this Structure

1PJW is a Single protein structure of sequence from Japanese encephalitis virus. Full crystallographic information is available from OCA.

Reference

Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein., Wu KP, Wu CW, Tsao YP, Kuo TW, Lou YC, Lin CW, Wu SC, Cheng JW, J Biol Chem. 2003 Nov 14;278(46):46007-13. Epub 2003 Sep 2. PMID:12952958 Page seeded by OCA on Sat May 3 05:10:12 2008

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