5h8x
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the complex MMP-8/BF471 (catechol inhibitor)== | |
| + | <StructureSection load='5h8x' size='340' side='right' caption='[[5h8x]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5h8x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H8X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H8X FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XT:~{N}-[3,4-BIS(OXIDANYL)PHENYL]-4-PHENYL-BENZENESULFONAMIDE'>5XT</scene>, <scene name='pdbligand=7FY:~{N}-[4,5-BIS(OXIDANYLIDENE)CYCLOHEXEN-1-YL]-4-PHENYL-BENZENESULFONAMIDE'>7FY</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h8x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h8x OCA], [http://pdbe.org/5h8x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h8x RCSB], [http://www.ebi.ac.uk/pdbsum/5h8x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h8x ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN]] Can degrade fibrillar type I, II, and III collagens. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | New catechol-containing chemical entities have been investigated as matrix metalloproteinase inhibitors as well as antioxidant molecules. The combination of the two properties could represent a useful feature due to the potential application in all the pathological processes characterized by increased proteolytic activity and radical oxygen species (ROS) production, such as inflammation and photoaging. A series of catechol-based molecules were synthesized and tested for both proteolytic and oxidative inhibitory activity, and the detailed binding mode was assessed by crystal structure determination of the complex between a catechol derivative and the matrix metalloproteinase-8. Surprisingly, X-ray structure reveals that the catechol oxygens do not coordinates the zinc atom. | ||
| - | + | Catechol-based matrix metalloproteinase inhibitors with additional antioxidative activity.,Tauro M, Laghezza A, Loiodice F, Piemontese L, Caradonna A, Capelli D, Montanari R, Pochetti G, Di Pizio A, Agamennone M, Campestre C, Tortorella P J Enzyme Inhib Med Chem. 2016 Aug 24:1-13. PMID:27556138<ref>PMID:27556138</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 5h8x" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Neutrophil collagenase]] | ||
[[Category: Capelli, D]] | [[Category: Capelli, D]] | ||
| - | [[Category: Pochetti, G]] | ||
[[Category: Montanari, R]] | [[Category: Montanari, R]] | ||
| + | [[Category: Pochetti, G]] | ||
| + | [[Category: Tortorella, P]] | ||
| + | [[Category: Catechol function]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Metalloprotese]] | ||
| + | [[Category: Mmp]] | ||
| + | [[Category: Zinc binding function]] | ||
Revision as of 18:14, 2 November 2016
Crystal structure of the complex MMP-8/BF471 (catechol inhibitor)
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