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1pnn

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[[Image:1pnn.gif|left|200px]]
[[Image:1pnn.gif|left|200px]]
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{{Structure
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|PDB= 1pnn |SIZE=350|CAPTION= <scene name='initialview01'>1pnn</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1pnn", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=IPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-5-IODOURACIL'>IPN</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1pnn| PDB=1pnn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pnn OCA], [http://www.ebi.ac.uk/pdbsum/1pnn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pnn RCSB]</span>
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}}
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'''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA'''
'''PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA'''
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==About this Structure==
==About this Structure==
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1PNN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PNN OCA].
==Reference==
==Reference==
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525381 8525381]
A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8525381 8525381]
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[[Category: Protein complex]]
 
[[Category: Betts, L.]]
[[Category: Betts, L.]]
[[Category: Veal, J M.]]
[[Category: Veal, J M.]]
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[[Category: hairpin pna:dna triplex]]
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[[Category: Hairpin pna:dna triplex]]
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[[Category: triplex watson-crick hoogsteen]]
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[[Category: Triplex watson-crick hoogsteen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:17:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:02:03 2008''
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Revision as of 02:17, 3 May 2008

Image:1pnn.gif

Template:STRUCTURE 1pnn

PEPTIDE NUCLEIC ACID (PNA) COMPLEXED WITH DNA


Overview

The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.

About this Structure

Full crystallographic information is available from OCA.

Reference

A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex., Betts L, Josey JA, Veal JM, Jordan SR, Science. 1995 Dec 15;270(5243):1838-41. PMID:8525381 Page seeded by OCA on Sat May 3 05:17:08 2008

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