5m55

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m (Protected "5m55" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5m55 is ON HOLD
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==Nek2 bound to arylaminopurine 71==
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<StructureSection load='5m55' size='340' side='right' caption='[[5m55]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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Authors: Bayliss, R.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5m55]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M55 FirstGlance]. <br>
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Description: Nek2 bound to arylaminopurine 71
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7GG:6-[(~{Z})-2-(DIETHYLAMINO)ETHENYL]-~{N}-PHENYL-7~{H}-PURIN-2-AMINE'>7GG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m55 OCA], [http://pdbe.org/5m55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m55 RCSB], [http://www.ebi.ac.uk/pdbsum/5m55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m55 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NEK2_HUMAN NEK2_HUMAN]] Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.<ref>PMID:11742531</ref> <ref>PMID:14978040</ref> <ref>PMID:12857871</ref> <ref>PMID:15358203</ref> <ref>PMID:15388344</ref> <ref>PMID:15161910</ref> <ref>PMID:17283141</ref> <ref>PMID:17621308</ref> <ref>PMID:17626005</ref> <ref>PMID:18086858</ref> <ref>PMID:18297113</ref> <ref>PMID:20034488</ref> <ref>PMID:21076410</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Bayliss, R]]
[[Category: Bayliss, R]]
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[[Category: Centrosome separation]]
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[[Category: Inhibitor]]
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[[Category: Protein kinase]]
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[[Category: Transferase]]

Revision as of 18:31, 2 November 2016

Nek2 bound to arylaminopurine 71

5m55, resolution 2.40Å

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