1pob

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[[Image:1pob.gif|left|200px]]
[[Image:1pob.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pob |SIZE=350|CAPTION= <scene name='initialview01'>1pob</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1pob", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GEL:1-O-OCTYL-2-HEPTYLPHOSPHONYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>GEL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1pob| PDB=1pob | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pob OCA], [http://www.ebi.ac.uk/pdbsum/1pob PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pob RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''
'''CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''
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Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2274787 2274787]
Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2274787 2274787]
[[Category: Naja atra]]
[[Category: Naja atra]]
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[[Category: Phospholipase A(2)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Otwinowski, Z.]]
[[Category: Otwinowski, Z.]]
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: White, S P.]]
[[Category: White, S P.]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:18:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:02:23 2008''
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Revision as of 02:18, 3 May 2008

Image:1pob.gif

Template:STRUCTURE 1pob

CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE


Overview

The crystal structure of a complex between a phosphonate transition-state analogue and the phospholipase A2 (PLA2) from Naja naja atra venom has been solved and refined to a resolution of 2.0 angstroms. The identical stereochemistry of the two complexes that comprise the crystal's asymmetric unit indicates both the manner in which the transition state is stabilized and how the hydrophobic fatty acyl chains of the substrate are accommodated by the enzyme during interfacial catalysis. The critical features that suggest the chemistry of binding and catalysis are the same as those seen in the crystal structure of a similar complex formed with the evolutionarily distant bee-venom PLA2.

About this Structure

1POB is a Single protein structure of sequence from Naja atra. Full crystallographic information is available from OCA.

Reference

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:2274787 Page seeded by OCA on Sat May 3 05:18:18 2008

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OCA

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