1ptq

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[[Image:1ptq.gif|left|200px]]
[[Image:1ptq.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1ptq", creates the "Structure Box" on the page.
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{{STRUCTURE_1ptq| PDB=1ptq | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ptq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ptq OCA], [http://www.ebi.ac.uk/pdbsum/1ptq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ptq RCSB]</span>
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'''PROTEIN KINASE C DELTA CYS2 DOMAIN'''
'''PROTEIN KINASE C DELTA CYS2 DOMAIN'''
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[[Category: Hurley, J H.]]
[[Category: Hurley, J H.]]
[[Category: Zhang, G.]]
[[Category: Zhang, G.]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:28:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:04:23 2008''
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Revision as of 02:28, 3 May 2008

Image:1ptq.gif

Template:STRUCTURE 1ptq

PROTEIN KINASE C DELTA CYS2 DOMAIN


Overview

Protein kinase Cs (PKCs) are a ubiquitous family of regulatory enzymes that associate with membranes and are activated by diacylglycerol or tumor-promoting agonists such as phorbol esters. The structure of the second activator-binding domain of PKC delta has been determined in complex with phorbol 13-acetate, which binds in a groove between two pulled-apart beta strands at the tip of the domain. The C3, C4, and C20 phorbol oxygens form hydrogen bonds with main-chain groups whose orientation is controlled by a set of highly conserved residues. Phorbol binding caps the groove and forms a contiguous hydrophobic surface covering one-third of the domain, explaining how the activator promotes insertion of PKC into membranes.

About this Structure

1PTQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester., Zhang G, Kazanietz MG, Blumberg PM, Hurley JH, Cell. 1995 Jun 16;81(6):917-24. PMID:7781068 Page seeded by OCA on Sat May 3 05:28:26 2008

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