1ptw

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[[Image:1ptw.jpg|left|200px]]
[[Image:1ptw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1ptw |SIZE=350|CAPTION= <scene name='initialview01'>1ptw</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1ptw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PDE4D2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1ptw| PDB=1ptw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ptw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ptw OCA], [http://www.ebi.ac.uk/pdbsum/1ptw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ptw RCSB]</span>
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}}
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'''The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis'''
'''The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis'''
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[[Category: Huai, Q.]]
[[Category: Huai, Q.]]
[[Category: Ke, H.]]
[[Category: Ke, H.]]
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[[Category: binuclear catalysis]]
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[[Category: Binuclear catalysis]]
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[[Category: camp hydrolysis crystal structure]]
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[[Category: Camp hydrolysis crystal structure]]
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[[Category: catalytic mechanism]]
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[[Category: Catalytic mechanism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:28:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:04:29 2008''
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Revision as of 02:28, 3 May 2008

Image:1ptw.jpg

Template:STRUCTURE 1ptw

The Crystal Structure of AMP-Bound PDE4 Suggests a Mechanism for Phosphodiesterase Catalysis


Overview

Cyclic nucleotide phosphodiesterases (PDEs) regulate the intracellular concentrations of cyclic 3',5'-adenosine and guanosine monophosphates (cAMP and cGMP, respectively) by hydrolyzing them to AMP and GMP, respectively. Family-selective inhibitors of PDEs have been studied for treatment of various human diseases. However, the catalytic mechanism of cyclic nucleotide hydrolysis by PDEs has remained unclear. We determined the crystal structure of the human PDE4D2 catalytic domain in complex with AMP at 2.4 A resolution. In this structure, two divalent metal ions simultaneously interact with the phosphate group of AMP, implying a binuclear catalysis. In addition, the structure suggested that a hydroxide ion or a water bridging two metal ions may serve as the nucleophile for the hydrolysis of the cAMP phosphodiester bond.

About this Structure

1PTW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis., Huai Q, Colicelli J, Ke H, Biochemistry. 2003 Nov 18;42(45):13220-6. PMID:14609333 Page seeded by OCA on Sat May 3 05:28:38 2008

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