5cyx
From Proteopedia
(Difference between revisions)
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==Crystal Structure of Mouse Protocadherin-24 EC1-3== | ==Crystal Structure of Mouse Protocadherin-24 EC1-3== | ||
| - | <StructureSection load='5cyx' size='340' side='right' caption='[[5cyx]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='5cyx' size='340' side='right'caption='[[5cyx]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5cyx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CYX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5cyx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CYX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CYX FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5co1|5co1]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5co1|5co1]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cdhr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyx OCA], [http://pdbe.org/5cyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cyx RCSB], [http://www.ebi.ac.uk/pdbsum/5cyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyx ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cyx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cyx OCA], [http://pdbe.org/5cyx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cyx RCSB], [http://www.ebi.ac.uk/pdbsum/5cyx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cyx ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/CDHR2_MOUSE CDHR2_MOUSE]] Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.[UniProtKB:Q9BYE9] | [[http://www.uniprot.org/uniprot/CDHR2_MOUSE CDHR2_MOUSE]] Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells.[UniProtKB:Q9BYE9] | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cadherin 3D structures|Cadherin 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lk3 transgenic mice]] | ||
[[Category: Johnson, Z R]] | [[Category: Johnson, Z R]] | ||
[[Category: Sotomayor, M]] | [[Category: Sotomayor, M]] | ||
Revision as of 10:29, 1 April 2020
Crystal Structure of Mouse Protocadherin-24 EC1-3
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