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1pvu

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[[Image:1pvu.jpg|left|200px]]
[[Image:1pvu.jpg|left|200px]]
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{{Structure
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|PDB= 1pvu |SIZE=350|CAPTION= <scene name='initialview01'>1pvu</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1pvu", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Type_II_site-specific_deoxyribonuclease Type II site-specific deoxyribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.21.4 3.1.21.4] </span>
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{{STRUCTURE_1pvu| PDB=1pvu | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pvu OCA], [http://www.ebi.ac.uk/pdbsum/1pvu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pvu RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF PVUII ENDONUCLEASE REVEALS EXTENSIVE STRUCTURAL HOMOLOGIES TO ECORV'''
'''THE CRYSTAL STRUCTURE OF PVUII ENDONUCLEASE REVEALS EXTENSIVE STRUCTURAL HOMOLOGIES TO ECORV'''
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[[Category: Athanasiadis, A.]]
[[Category: Athanasiadis, A.]]
[[Category: Vlassi, M.]]
[[Category: Vlassi, M.]]
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[[Category: type ii restriction endonuclease]]
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[[Category: Type ii restriction endonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:32:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:05:15 2008''
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Revision as of 02:32, 3 May 2008

Image:1pvu.jpg

Template:STRUCTURE 1pvu

THE CRYSTAL STRUCTURE OF PVUII ENDONUCLEASE REVEALS EXTENSIVE STRUCTURAL HOMOLOGIES TO ECORV


Overview

The crystal structure of the dimeric PvuII restriction endonuclease (R.PvuII) has been determined at a resolution of 2.4A. The protein has a mixed alpha/beta architecture and consists of two subdomains. Despite a lack of sequence homology, extensive structural similarities exist between one R.PvuII subdomain and the DNA-binding subdomain of EcoRV endonuclease (R.EcoRV); the dimerization subdomains are unrelated. Within the similar domains, flexible segments of R.PvuII are topologically equivalent to the DNA-binding turns of R.EcoRV; potential catalytic residues can be deduced from the structural similarities to R.EcoRV. Conformational flexibility is important for the interaction with DNA. A possible classification of endonuclease structures on the basis of the positions of the scissile phosphates is discussed.

About this Structure

1PVU is a Single protein structure of sequence from Proteus vulgaris. Full crystallographic information is available from OCA.

Reference

Crystal structure of PvuII endonuclease reveals extensive structural homologies to EcoRV., Athanasiadis A, Vlassi M, Kotsifaki D, Tucker PA, Wilson KS, Kokkinidis M, Nat Struct Biol. 1994 Jul;1(7):469-75. PMID:7664066 Page seeded by OCA on Sat May 3 05:32:43 2008

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