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Aldehyde dehydrogenase
From Proteopedia
(Difference between revisions)
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**[[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR /> | **[[3fx4]] – ALDH1 + NADP + inhibitor – pig<BR /> | ||
| - | **[[1bxs]] – | + | **[[1bxs]] – sALDH1 + NAD - sheep<br /> |
| + | **[[5abm]] - sALDH1 + NAD derivative<br /> | ||
| + | **[[5ac0]] - sALDH1 + NAD + duocarmycin analog<br /> | ||
| + | **[[5ac1]], [[5ac2]] - sALDH1 + duocarmycin analog<br /> | ||
**[[1o9j]] – ALDH1 + NAD – Elephant shrew<br /> | **[[1o9j]] – ALDH1 + NAD – Elephant shrew<br /> | ||
**[[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br /> | **[[3rhj]], [[3rhl]], [[3rho]], [[3rhp]], [[3rhq]], [[3rhr]] – rALDH1 C- terminal (mutant) + NADP – rat<br /> | ||
**[[3rhm]] - rALDH1 C- terminal<br /> | **[[3rhm]] - rALDH1 C- terminal<br /> | ||
| - | **[[1hso]] – hALDH1 α subunit + Zn + NAD<br /> | + | **[[1hso]] – hALDH1 α subunit + Zn + NAD - human<br /> |
| + | **[[4wj9]] - hALDH1 (mutant) <br /> | ||
| + | **[[4wpn]] - hALDH1 + inhibitor<br /> | ||
| + | **[[4wp7]] - hALDH1 (mutant) + inhibitor<br /> | ||
| + | **[[4wb9]] - hALDH1 + NAD derivative <br /> | ||
| + | **[[4x4l]] - hALDH1 + NAD derivative + inhibitor<br /> | ||
**[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD | **[[1ht0]] – hALDH1 γ subunit (mutant) + Zn + NAD | ||
*ALDH class 2 | *ALDH class 2 | ||
| - | **[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517 | + | **[[3n80]], [[1o05]], [[4kwf]] – hALDH2 residues 18-517<BR /> |
**[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR /> | **[[3n81]], [[2onn]], [[2ono]], [[1zum]] – hALDH2 residues 18-517 (mutant) <BR /> | ||
**[[1ag8]] – bALDH NAD binding domain - bovine | **[[1ag8]] – bALDH NAD binding domain - bovine | ||
| Line 47: | Line 55: | ||
**[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR /> | **[[3inj]], [[3inl]], [[4kwg]] - hALDH2 residues 18-517 + agonist<BR /> | ||
**[[2vle]] - hALDH2 residues 24-517 + daidzin<BR /> | **[[2vle]] - hALDH2 residues 24-517 + daidzin<BR /> | ||
| - | **[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]] - hALDH2 residues 18-517 + NAD<BR /> | + | **[[1nzx]], [[1nzz]], [[1o00]], [[1o02]], [[1cw3]], [[4x2q]] - hALDH2 residues 18-517 + NAD<BR /> |
**[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR /> | **[[3n82]], [[3n83]], [[2onm]], [[2onp]], [[1nzw]], [[1o04]] – hALDH2 residues 18-517 (mutant) + NADH<BR /> | ||
**[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br /> | **[[3sz9]] - hALDH2 residues 18-517 + inhibitor<br /> | ||
**[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> | **[[1a4z]] – bALDH2 NAD-binding domain + NAD<BR /> | ||
| + | **[[1bi9]] – rALDH2 + NAD<br /> | ||
| + | **[[4pxl]] – ALDH2 + NAD - maize<br /> | ||
*ALDH2 ternary complex | *ALDH2 ternary complex | ||
| Line 73: | Line 83: | ||
**[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> | **[[4mpb]], [[4nu9]], [[4q92]], [[4qto]] - Betaine-SaALDH – ''Staphylococcus aureus''<BR /> | ||
**[[4qje]] - Betaine-SaALDH (mutant)<br /> | **[[4qje]] - Betaine-SaALDH (mutant)<br /> | ||
| + | **[[4zxu]], [[4zwl]] - Betaine-SaALDH (mutant) + NAD<br /> | ||
**[[4cbb]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br /> | **[[4cbb]] - Betaine-PaALDH - ''Pseudomonas aeruginosa''<br /> | ||
**[[1a4s]] - Betaine-cALDH - cod<BR /> | **[[1a4s]] - Betaine-cALDH - cod<BR /> | ||
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**[[3r64]] – ALDH – ''Corynebacterium glutamicum''<br /> | **[[3r64]] – ALDH – ''Corynebacterium glutamicum''<br /> | ||
**[[3rhe]] – Benzaldehyde-ALDH – ''Legionella pneumophila''<br /> | **[[3rhe]] – Benzaldehyde-ALDH – ''Legionella pneumophila''<br /> | ||
| - | **[[3u4j]], [[4i3t]] – SmALDH – ''Sinorhizobium meliloti'' | + | **[[3u4j]], [[4i3t]] – SmALDH – ''Sinorhizobium meliloti''<br /> |
| + | **[[5dru]] - CpALDH – ''Clostridium phytofermentans''<br /> | ||
| + | **[[4qf6]], [[4ps9]] – BcALDH – ''Bacillus cereus''<br /> | ||
| + | **[[4qet]] – BcALDH (mutant)<br /> | ||
*NAD-dependent ALDH binary complexes | *NAD-dependent ALDH binary complexes | ||
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**[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | **[[2w8q]] - Succinate–semi-hALDH family 5 + succinic acid<BR /> | ||
**[[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR /> | **[[4mpy]], [[4nea]] - Betaine-SaALDH + NAD<BR /> | ||
| - | **[[4qn2]] - Betaine-SaALDH (mutant) + NAD<br /> | + | **[[4qn2]], [[5ez4]], [[5eyu]], [[5dib]] - Betaine-SaALDH (mutant) + NAD<br /> |
**[[1bpw]] - Betaine-cALDH + NAD<BR /> | **[[1bpw]] - Betaine-cALDH + NAD<BR /> | ||
**[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | **[[2j6l]] – Aminoadipate-semi-hALDH family 7 + NAD<BR /> | ||
**[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | **[[2cfi]] - Formyltetrahydrofolate-hALDH hydrolase domain + formyltetrahydropterin<BR /> | ||
| - | **[[2nad]] - Formate-PaALDH | + | **[[2nad]] - Formate-PaALDH + NAD <BR /> |
| - | + | ||
**[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br /> | **[[3l4p]], [[1sij]] – ALDH + AsO3 – ''Desulfovibrio gigas''<br /> | ||
| - | **[[4a0m]] – spALDH + NAD – spinach<br /> | + | **[[4a0m]], [[4v37]] – spALDH + NAD – spinach<br /> |
| + | **[[5a2d]], [[4v3f]] – spALDH + choline<br /> | ||
**[[3iwk]] – amino-ALDH + NAD – pea<br /> | **[[3iwk]] – amino-ALDH + NAD – pea<br /> | ||
**[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD <br /> | **[[3ju8]] - Succinylglutamic–semi-PaALDH + NAD <br /> | ||
**[[4caz]] - Betaine-PaALDH + NAD derivative<br /> | **[[4caz]] - Betaine-PaALDH + NAD derivative<br /> | ||
| - | **[[4c3s]] - | + | **[[4c3s]] - CpALDH + NAD <br /> |
| + | **[[5dbv]] - CpALDH + CoA <br /> | ||
**[[4i3u]] – SmALDH + phosphonoacetaldehyde<br /> | **[[4i3u]] – SmALDH + phosphonoacetaldehyde<br /> | ||
| + | **[[4pt0]] – BcALDH + NAD<br /> | ||
*NAD-dependent ALDH ternary complexes | *NAD-dependent ALDH ternary complexes | ||
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**[[3ifg]], [[3ifh]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br /> | **[[3ifg]], [[3ifh]] - Succinate–semi-ALDH – ''Burkholderia pseudomallei''<br /> | ||
**[[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br /> | **[[3rh9]] - Succinate–semi-ALDH – ''Marinobacter aquaeolei''<br /> | ||
| - | **[[3uw3]] - aspartate–semi- | + | **[[3uw3]] - aspartate–semi-BtALDH – ''Burkholderia thailandensis''<br /> |
**[[3v4c]] - SmALDH<br /> | **[[3v4c]] - SmALDH<br /> | ||
**[[4gac]] – ALDH – mouse<br /> | **[[4gac]] – ALDH – mouse<br /> | ||
| + | **[[5eeb]] - PfALDH – ''Pyrobaculum ferrireducens''<br /> | ||
*NADP-dependent ALDH binary complexes | *NADP-dependent ALDH binary complexes | ||
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**[[3jz4]] - Succinate–semi-EcALDH + NADP<br /> | **[[3jz4]] - Succinate–semi-EcALDH + NADP<br /> | ||
**[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br /> | **[[3hsk]] - aspartate–semi-ALDH + NADP – ''Candida albicans''<br /> | ||
| - | **[[4h73]], [[4nmj]], [[4nmk]] - ALDH + NADP – '' | + | **[[4h73]], [[4nmj]], [[4nmk]], [[5f2c]], [[5exf]], [[5euy]], [[5ekc]], [[5ek6]] - PfALDH + NADP <br /> |
| + | **[[5kf0]] - ALDH + NADP – ''Burkholderia vietnamiensis''<br /> | ||
| + | **[[5jry]] - ALDH + NADP – ''Burkholderia multivorans''<br /> | ||
| + | **[[5j6b]] - BtALDH + NADP <br /> | ||
| + | **[[4pt3]] – BcALDH + NADP<br /> | ||
*NADP-dependent ALDH ternary complexes | *NADP-dependent ALDH ternary complexes | ||
Revision as of 10:34, 27 February 2017
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3D Structures of Aldehyde dehydrogenase
Updated on 27-February-2017
References
- ↑ Keller, Markus A.; Zander, Ulrich; Fuchs, Julian E.; Kreutz, Christoph; Watschinger, Katrin et al. (2014). A gatekeeper helix determines the substrate specificity of Sjögren–Larsson Syndrome enzyme fatty aldehyde dehydrogenase. Nature Communications vol. 5.
