Sandbox 54321

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Function

Lisinopril is an orally active ACE inhibitor that is used to treat high blood pressure. Lisinopril works by antagonizing the effect of the RAAS, which is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. ACE inhibitors inhibit the rapid conversion of ATI to ATII, and also antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, which is a vasodilator. When the deactivation of bradykinin is inhibited, bradykinin levels are increased and this may further sustain the effects of lisinopril by by causing increased vasodilation and a decreased blood pressure. Overall, lisinopril inhibits the substance in the body that allows blood vessels to tighten, and as a result lisinopril relaxes the blood vessels and therefore lowers blood pressure and increased the supply of blood and oxygen to the heart.

Structure

is a synthetic angiotensin-converting enzyme inhibitor (ACE inhibitors) with molecular formula of C21+H31+N3+O5, empirical formula of C21+H31+N3+O5*2H2O, and average molecular weight of 405.495 g/mol. It is primarily used for the treatment of hypertension. Lisinopril is typically in the trans isometric form because it has a lower steric repulsion between the hydroxyl and carboxyl groups than the cis conformation and is biologically active in this form (Bouabdallah).Lisinopril has a benzene ring and from there it has a 4-carbon amide chain where it branches of into a carboxylic acid group one way and a secondary amide group the other way which connects to the rest of the molecule. From the secondary amide, the molecule branches into a 5-carbon amine with a primary amide at the end. The other branch from the secondary amide has a ketone bonded to a nitrogen in a 4-carbon ring. From this carbon ring, there is a carboxylic acid group.

Relevance

Structural highlights

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