Sandbox 54321
From Proteopedia
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== Function == | == Function == | ||
| - | Lisinopril is an orally active ACE inhibitor that is used to treat high blood pressure. Lisinopril works by antagonizing the effect of the RAAS, which is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance. ACE inhibitors inhibit the rapid conversion of ATI to ATII, and also antagonize RAAS-induced increases in blood pressure. ACE (also known as kininase II) is also involved in the enzymatic deactivation of bradykinin, which is a vasodilator. When the deactivation of bradykinin is inhibited, bradykinin levels are increased and this may further sustain the effects of lisinopril by by causing increased vasodilation and a decreased blood pressure. Overall, lisinopril inhibits the substance in the body that allows blood vessels to tighten, and as a result lisinopril relaxes the blood vessels and therefore lowers blood pressure and increased the supply of blood and oxygen to the heart. | ||
== Structure == | == Structure == | ||
| - | <scene name='74/745973/Lisinopril_zinc/1'>Lisinopril</scene>is a synthetic angiotensin-converting enzyme inhibitor (ACE inhibitors) with molecular formula of C21+H31+N3+O5 | + | <scene name='74/745973/Lisinopril_zinc/1'>Lisinopril</scene>is a synthetic angiotensin-converting enzyme inhibitor (ACE inhibitors) with molecular formula of C21+H31+N3+O5. It has an empirical formula of C21+H31+N3+O5*2H2O, and a average molecular weight of 405.495 g/mol. It is primarily used for the treatment of hypertension<ref name="one">Lisinopril. (2005, June 24). Retrieved October 26, 2016, from https://pubchem.ncbi.nlm.nih.gov/compound/lisinopril#section=Top |
| + | </ref>. Lisinopril is typically in the trans isometric form because it has a lower steric repulsion between the hydroxyl and carboxyl groups than the cis conformation and is biologically active in this form<ref name="two">Bouabdallah, S., Dhia, T. B., & Driss, R. (2014, February 25). Study of a Conformational Equilibrium of Lisinopril by HPLC, NMR, and DFT. Retrieved November 12, 2016, from https://www.hindawi.com/journals/ijac/2014/494719/</ref>.Lisinopril has a benzene ring and from there it has a 4-carbon amide chain where it branches of into a carboxylic acid group one way and a secondary amide group the other way which connects to the rest of the molecule. From the secondary amide, the molecule branches into a 5-carbon amine with a primary amide at the end. The other branch from the secondary amide has a ketone bonded to a nitrogen in a 4-carbon ring. From this carbon ring, there is a carboxylic acid group. | ||
== Relevance == | == Relevance == | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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| - | == Mechanism == | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:04, 12 November 2016
==Your Heading Here (maybe something like 'Structure')== 0
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Lisinopril. (2005, June 24). Retrieved October 26, 2016, from https://pubchem.ncbi.nlm.nih.gov/compound/lisinopril#section=Top
- ↑ Bouabdallah, S., Dhia, T. B., & Driss, R. (2014, February 25). Study of a Conformational Equilibrium of Lisinopril by HPLC, NMR, and DFT. Retrieved November 12, 2016, from https://www.hindawi.com/journals/ijac/2014/494719/
