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Eukaryotic initiation factor

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Line 26: Line 26:
**[[2ogh]] - yEIF1 – NMR<BR />
**[[2ogh]] - yEIF1 – NMR<BR />
**[[3j80]], [[3j81]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
**[[3j80]], [[3j81]] – EIF1A in 40S ribosome – ''Kluyveromyces lactis'' – cryo EM<br />
-
**[[4kzx]], [[4kzy]], [[4kzz]] – EIF1A in 40S ribosome – rabbit – cryo EM<br />
+
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
Line 39: Line 39:
**[[3wj9]] - EIF2A – fission yeast<br />
**[[3wj9]] - EIF2A – fission yeast<br />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
 +
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[3ecs]] – hEIF2B
**[[3ecs]] – hEIF2B
Line 48: Line 49:
**[[4u1f]] - yEIF3B middle domain<br />
**[[4u1f]] - yEIF3B middle domain<br />
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
**[[2krb]] - hEIF3B RNA recognition domain + hEIF3J peptide<br />
-
**[[4nox]] – EIF3B – ''Chaetomium thermophilum''<br />
+
**[[5k1h]] – hEIF3B + EIF3A C-terminal<br />
 +
**[[4nox]] – CtEIF3B – ''Chaetomium thermophilum''<br />
 +
**[[5krb]], [[5krc]], [[5krd]] – EIF3D – wasp<br />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
**[[2cq0]] – hEIF3G RNA recognition domain – NMR<BR />
**[[2mjc]] - hEIF3G residues 153-176 – NMR<br />
**[[2mjc]] - hEIF3G residues 153-176 – NMR<br />
Line 54: Line 57:
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
**[[4u1e]] - yEIF3B CTD + yEIF3I + yEIF3G NTD<br />
 +
**[[5a5u]] - rEIF3B + rEIF3I – Cryo EM<br />
 +
**[[5a5t]] - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM<br />
**[[3bpj]] – hEIF3J<BR />
**[[3bpj]] – hEIF3J<BR />
**[[1rz4]] – hEIF3K<br />
**[[1rz4]] – hEIF3K<br />
Line 65: Line 70:
**[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR />
**[[1wi8]], [[2j76]] – hEIF4B RNA recognition domain - NMR<BR />
**[[2gpq]], [[3tf2]] – hEIF4E<BR />
**[[2gpq]], [[3tf2]] – hEIF4E<BR />
 +
**[[5gw6]] – hEIF4E (mutant)<br />
**[[2wmc]] - EIF4E - pea<BR />
**[[2wmc]] - EIF4E - pea<BR />
**[[2idr]] – wEIF4E – wheat<BR />
**[[2idr]] – wEIF4E – wheat<BR />
Line 77: Line 83:
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<BR />
**[[4c9b]] - hEIF4A + CWC22<br />
**[[4c9b]] - hEIF4A + CWC22<br />
-
**[[2jgc]] - hEIF4E + 4E-BP1 peptide<br />
+
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
**[[4bea]] - hEIF4E + stapled peptide<br />
**[[4bea]] - hEIF4E + stapled peptide<br />
-
**[[1ejh]] – mEIF4E + EIF4G peptide + GDP – mouse<BR />
+
**[[5t46]] - hEIF4E + EIF4GI<br />
-
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide<br />
+
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
 +
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
**[[2idv]] - wEIF4E (mutant) + GDP<BR />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
**[[2w97]], [[4aza]] – hEIF4E + hEIF4G peptide<br />
**[[2w97]], [[4aza]] – hEIF4E + hEIF4G peptide<br />
-
**[[1wkw]] - hEIF4E + EIF4E-binding protein peptide + GDP<BR />
+
**[[2v8w]], [[2v8x]], [[2v8y]], [[3u7x]], [[2jgc]] - hEIF4E + EIF4E-BP1 peptide<br />
-
**[[2v8w]], [[2v8x]], [[2v8y]], [[3u7x]] - hEIF4E + EIF4E-binding protein peptide<br />
+
**[[3am7]], [[1wkw]] - hEIF4E + EIF4E-BP1 peptide + nucleotide<br />
-
**[[3am7]] - hEIF4E + EIF4E-binding protein peptide + nucleotide<br />
+
**[[1ej4]] - mEIF4E + EIF4E-BP1 peptide<br />
-
**[[1ej4]] - mEIF4E + EIF4E-binding protein peptide<br />
+
**[[5bxv]], [[1ejh]] - mEIF4E + nucleotide + 4E-BP1 peptide<br />
-
**[[3hxg]], [[3hxi]] - EIF4E + EIF4E-binding protein peptide + GDP – ''Schistosoma mansoni''<BR />
+
**[[3hxg]], [[3hxi]] - EIF4E + EIF4E-BP1 peptide + GDP – ''Schistosoma mansoni''<BR />
-
**[[3m93]], [[3m94]] - EIF4E + EIF4E-binding protein peptide + nucleotide – Pig roundworm<BR />
+
**[[3m93]], [[3m94]] - EIF4E + EIF4E-BP1 peptide + nucleotide – Pig roundworm<BR />
 +
**[[5abx]], [[5aby]] - EIF4E + EIF4E-BP1 peptide + nucleotide – roundworm<br />
**[[1ap8]] – yEIF4E + GDP – NMR<BR />
**[[1ap8]] – yEIF4E + GDP – NMR<BR />
**[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR />
**[[1rf8]] - yEIF4E + yEIF4GI peptide + GDP<BR />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<BR />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<BR />
**[[4axg]] - DmEIF4E + protein CUP – ''Drosophila melanogaster''<br />
**[[4axg]] - DmEIF4E + protein CUP – ''Drosophila melanogaster''<br />
-
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]] - DmEIF4E + 4E-binding protein <br />
+
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-BP1 <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
-
**[[4uec]] - DmEIF4E + DmEIF4G <br />
+
**[[4uec]], [[5t47]], [[5t48]] - DmEIF4E + DmEIF4G <br />
*EIF5
*EIF5
Line 107: Line 115:
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
 +
**[[5hy6]] – EIF5A – armywarm<br />
**[[3cpf]] - hEIF<br />
**[[3cpf]] - hEIF<br />
**[[2ful]] – yEIF5 CTD<br />
**[[2ful]] – yEIF5 CTD<br />
Line 113: Line 122:
**[[2e9h]] – hEIF5 – NMR<br />
**[[2e9h]] – hEIF5 – NMR<br />
**[[3cpf]] – hEIF5A<br />
**[[3cpf]] – hEIF5A<br />
 +
**[[5dlq]] – hEIF5A + exportin 4 + GTPase RAN + GTP<br />
**[[3er0]] - yEIF5A<br />
**[[3er0]] - yEIF5A<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbk]] – yEIF5B + yEIF1A<br />
**[[3wbk]] – yEIF5B + yEIF1A<br />
**[[4ncf]] – yEIF5B + nucleotide<br />
**[[4ncf]] – yEIF5B + nucleotide<br />
 +
**[[4tmt]], [[4tmv]], [[4tmw]], [[4tmx]], [[4tmz]], [[4tn1]] – CtEIF5B (mutant) + nucleotide<br />
*EIF6
*EIF6
Line 123: Line 134:
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
**[[3j2i]] – yEIF6 + proliferation-associated protein 2G4 – cryo EM<br />
 +
**[[5m3q]] – CtEIF6 <br />
}}
}}
== References ==
== References ==
<references/>
<references/>

Revision as of 08:41, 10 May 2017

Human initiation factor EIF4E complex with 7-methyl GPPPA 1ipb

Drag the structure with the mouse to rotate

3D structures of eukaryotic initiation factor

Updated on 10-May-2017

References

  1. ↑ Jivotovskaya AV, Valasek L, Hinnebusch AG, Nielsen KH. Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast. Mol Cell Biol. 2006 Feb;26(4):1355-72. PMID:16449648 doi:http://dx.doi.org/10.1128/MCB.26.4.1355-1372.2006
  2. ↑ Hershey JW. The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 2015 Jul;1849(7):792-800. doi:, 10.1016/j.bbagrm.2014.10.005. Epub 2014 Nov 1. PMID:25450521 doi:http://dx.doi.org/10.1016/j.bbagrm.2014.10.005

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Michal Harel, Joel L. Sussman, Alexander Berchansky

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