Beta-lactamase

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Line 33: Line 33:
**[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
**[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
 +
**[[5chu]], [[5cgs]] – EcBlac FOX-4<br />
 +
**[[5cgw]] – EcBlac FOX-4 (mutant)<br />
 +
**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
-
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcBlac A Toho-1 (mutant) <br />
 
-
**[[2xqz]], [[2wyx]] - EcBlac A Toho-1 (mutant) – Neutron<br />
 
-
**[[3c5a]] – EcBlac A Kpc-2<br />
 
-
**[[1ylj]], [[1ylp]], [[1ylt]], [[1ylw]], [[1yly]], [[1ylz]], [[1ym1]], [[1yms]], [[1ymx]], [[2p74]] – EcBlac A Ctx-M<br />
 
-
**[[3hre]] - EcBlac A Ctx-M (mutant) <br />
 
**[[3o3v]] – EcBlac peptidase domain<br />
**[[3o3v]] – EcBlac peptidase domain<br />
**[[1o7e]], [[1n4o]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
**[[1o7e]], [[1n4o]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
Line 45: Line 43:
**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br />
**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br />
**[[1n9b]] – KpBlac A Shv-2<br />
**[[1n9b]] – KpBlac A Shv-2<br />
 +
**[[5haq]], [[5hap]] - KpBlac A (mutant) <br />
**[[2qpn]] – KpBlac A Ges-1<br />
**[[2qpn]] – KpBlac A Ges-1<br />
**[[3ni9]] - PaBlac A Ges-2<br />
**[[3ni9]] - PaBlac A Ges-2<br />
Line 50: Line 49:
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
**[[3blm]] – SaBlac A<br />
**[[3blm]] – SaBlac A<br />
-
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
+
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
Line 56: Line 55:
**[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3s4x]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
-
**[[4c6y]], [[4c75]] – Blac – synthetic<br />
+
**[[4c6y]], [[4c75]], [[5fqm]] – Blac – synthetic<br />
-
 
+
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
-
*Extended-spectrum β-lactamase class A
+
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
-
 
+
**[[4yfm]] – Blac – ''Mycobacterium abscessus''<br />
-
**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
+
-
**[[3nia]] - PaESBL A GES-2 + inhibitor<br />
+
-
**[[4qu3]] - PaESBL A GES-2 + antibiotic<br />
+
-
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
+
-
**[[3v3s]] – PaESBL GES-18<br />
+
-
**[[1e25]] – PaESBL PER-1 (mutant)<br />
+
-
**[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br />
+
-
**[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br />
+
-
**[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br />
+
-
**[[3v3r]] - AbESBL A GES-11– ''Acinetobacter baumannii''<br />
+
-
**[[3tsg]] – AbESBL GES-14<br />
+
-
**[[2qpn]] – KpESBL A GES-1<br />
+
-
**[[3ni9]] - PaESBL A GES-2<br />
+
-
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]] - EcBlac A Ctx-M-9 + inhibitor<br />
+
-
**[[4len]] - EcBlac A Ctx-M-9 (mutant) + inhibitor<br />
+
-
**[[3hlw]], [[3huo]], [[3hvf]] - EcBlac A Ctx-M-9 (mutant) + antibiotic<br />
+
-
**[[4pm8]] - KpBlac A Ctx-M-14 <br />
+
-
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br />
+
-
**[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br />
+
-
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br />
+
-
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /
+
-
**[[4hbt]] – EcESBL Ctx-M-15<br />
+
-
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
+
*β-lactamase class A binary complex
*β-lactamase class A binary complex
-
**[[1axb]] - EcBlac A (mutant) + transition state analog<br />
+
**[[1axb]], [[5ksc]] - EcBlac A (mutant) + transition state analog<br />
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
 +
**[[5ujo]] - EcBlac A (mutant) + organometallics<br />
 +
**[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br />
 +
**[[5fa7]] - EcBlac A + inhibitor<br />
 +
**[[5chm]], [[5chj]] – EcBlac FOX-4 + antibiotic<br />
 +
**[[5cgx]] – EcBlac FOX-4 (mutant) + antibiotic<br />
 +
**[[4zj3]] – EcBlac Tem (mutant) + antibiotic<br />
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
-
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]] - KpBlac A Shv-1 + inhibitor<br />
+
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]], [[5ee8]], [[4zam]] - KpBlac A Shv-1 + inhibitor<br />
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
 +
**[[5t66]] - KpBlac A + boronic acid inhibitor<br />
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br />
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br />
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
-
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]] - BlBlac A (mutant) + antibiotic<br />
+
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]], [[5ghz]], [[5ghy]] - BlBlac A (mutant) + antibiotic<br />
**[[4m3k]], [[4n1h]] - BlBlac A + antibody<br />
**[[4m3k]], [[4n1h]] - BlBlac A + antibody<br />
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
**[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
**[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
-
**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''
+
**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''<br />
 +
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br />
 +
**[[5l2f]] - AbBlac A + antibiotic<br />
 +
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br />
 +
 
 +
*Extended-spectrum β-lactamase class A
 +
 
 +
**[[3ni9]] - PaESBL A GES-2<br />
 +
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
 +
**[[5f83]], [[5f82]] - PaESBL A GES-5 (mutant)<br />
 +
**[[3v3s]] – PaESBL GES-18<br />
 +
**[[1e25]] – PaESBL PER-1 (mutant)<br />
 +
**[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br />
 +
**[[4wz5]] – PaESBL Oxa-10 <br />
 +
**[[4yin]] – PaESBL Oxa-145 <br />
 +
**[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br />
 +
**[[5kzh]] - AbESBL A - ''Acinetobacter baumannii''<br />
 +
**[[3v3r]] - AbESBL A GES-11<br />
 +
**[[3tsg]] – AbESBL GES-14<br />
 +
**[[4oqi]], [[4op8]], [[4op5]] - EcESBL Tem-1 (mutant)<br />
 +
**[[4opy]] - EcESBL Tem-63 (mutant)<br />
 +
**[[4opr]], [[4opq]] - EcESBL Tem-94 (mutant)<br />
 +
**[[1ylj]], [[2p74]] – EcESBL Ctx-M-9<br />
 +
**[[3hre]] - EcESBL Ctx-M-9 (mutant)<br />
 +
**[[4ua6]] – EcESBL Ctx-M-14 <br />
 +
**[[1ylt]] - EcBlac A Ctx-M-14 (mutant)<br />
 +
**[[4hbt]] – EcESBL Ctx-M-15<br />
 +
**[[1ylw]] - EcESBL Ctx-M-16<br />
 +
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br />
 +
**[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br />
 +
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcESBLToho-1 (mutant) <br />
 +
**[[2xqz]], [[2wyx]] - EcESBL Toho-1 (mutant) – Neutron<br />
 +
**[[3zny]] - KpBlac A Ctx-M-12A (mutant) <br />
 +
**[[4pm8]] - KpBlac A Ctx-M-14 <br />
 +
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br />
 +
**[[2qpn]] – KpESBL A GES-1<br />
 +
 
 +
*Extended-spectrum β-lactamase class A binary complex
 +
 
 +
**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
 +
**[[3nia]] - PaESBL A GES-2 + inhibitor<br />
 +
**[[4qu3]] - PaESBL A GES-2 + antibiotic<br />
 +
**[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br />
 +
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br />
 +
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br />
 +
**[[1ymx]] - EcESBL Ctx-M-9 + antibiotic<br />
 +
**[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br />
 +
**[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br />
 +
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br />
 +
**[[4xxr]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
 +
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
 +
**[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br />
 +
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br />
 +
**[[5g18]] - EcESBL Ctx-M-97 + substrate<br />
 +
**[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br />
 +
**[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br />
 +
**[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br />
 +
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br />
 +
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br />
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
Line 118: Line 159:
*'''β-lactamase class B (Zn containing)'''
*'''β-lactamase class B (Zn containing)'''
-
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]] – BcBlac B - ''Bacillus cereus''<br />
+
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]], [[5fqa]] – BcBlac B - ''Bacillus cereus''<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
Line 131: Line 172:
**[[4d1t]] - PaBlac B Vim-7<br />
**[[4d1t]] - PaBlac B Vim-7<br />
**[[4d1u]], [[4d1v]], [[4d1w]] - PaBlac B Vim-7 (mutant)<br />
**[[4d1u]], [[4d1v]], [[4d1w]] - PaBlac B Vim-7 (mutant)<br />
-
**[[4awy]], [[4awz]] - PaBlac B Aim-1<br />
+
**[[4awy]], [[4awz]], [[4p62]] - PaBlac B Aim-1<br />
**[[2ynt]], [[2ynu]], [[2ynv]], [[2ynw]] - PaBlac B Gim-1<br />
**[[2ynt]], [[2ynu]], [[2ynv]], [[2ynw]] - PaBlac B Gim-1<br />
 +
**[[5act]], [[5acs]], [[5acr]], [[5acq]], [[5acp]] - PaBlac B Gim-1 (mutant)<br />
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
Line 140: Line 182:
**[[4uam]] - PaBlac Imp-1 <br />
**[[4uam]] - PaBlac Imp-1 <br />
**[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br />
**[[4f6h]], [[4f6z]] – PaBlac Imp-1 (mutant)<br />
-
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) – ''Serratia marcescens''<br />
+
**[[5b3r]] - PaBlac Imp-18 <br />
 +
**[[5ev6]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
 +
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) <br />
**[[3vpe]] - SmBlac Smb-1<br />
**[[3vpe]] - SmBlac Smb-1<br />
 +
**[[5fdh]] - SmBlac Oxa-405<br />
**[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – ''Thermus thermophilus''<br />
**[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – ''Thermus thermophilus''<br />
**[[2zzi]] – TtBlac B (Fe) <br />
**[[2zzi]] – TtBlac B (Fe) <br />
Line 155: Line 200:
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
**[[3s0z]] - EcBlac B Ndm-1<br />
**[[3s0z]] - EcBlac B Ndm-1<br />
 +
**[[4tz9]] - EcBlac B Ndm-3<br />
 +
**[[4tyf]] - EcBlac B Ndm-4<br />
 +
**[[4tzf]] - EcBlac B Ndm-8<br />
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
**[[4ubq]] - AbBlac Imp-2 <br />
**[[4ubq]] - AbBlac Imp-2 <br />
**[[3pg4]] – KpBlac Ndm-1<br />
**[[3pg4]] – KpBlac Ndm-1<br />
 +
**[[5a87]] - KpBlac B Vim-5<br />
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
-
**[[4wd6]] – Blac Dim-1 – ''Pseudomonas stutzeri''<br />
+
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
 +
**[[5iqk]] – Blac – uncultured<br />
 +
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
 +
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
*β-lactamase class B binary complex
*β-lactamase class B binary complex
Line 167: Line 219:
**[[1jt1]] – FgBlac + captopril <br />
**[[1jt1]] – FgBlac + captopril <br />
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]] - PaBlac B Imp-1+ inhibitor<br />
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]] - PaBlac B Imp-1+ inhibitor<br />
-
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]] - PaBlac B Vim-2 + inhibitor<br />
+
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]] - PaBlac B Vim-2 + inhibitor<br />
**[[4s2o]] - PaBlac Oxa-10 + antibiotic<br />
**[[4s2o]] - PaBlac Oxa-10 + antibiotic<br />
 +
**[[5fq9]] - PaBlac Oxa-10 + inhibitor<br />
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
-
**[[1vgn]], [[3vqz]] - SmBlac Imp-1+ inhibitor<br />
+
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]] - SmBlac Imp-1+ inhibitor<br />
 +
**[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br />
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
 +
**[[4zej]] - PsBlac Dim-1 + antibiotic<br />
**[[2aio]] – StmBlac B + antibiotic<br />
**[[2aio]] – StmBlac B + antibiotic<br />
-
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]] - StmBlac B + inhibitor<br />
+
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]] - StmBlac B + inhibitor<br />
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
-
**[[1x8g]], [[2gkl]] – AhBlac B + inhibitor<br />
+
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br />
-
**[[2qds]] – AhBlac B + captopril<br />
+
**[[3m8t]] – BjBlac B + inhibitor<br />
**[[3m8t]] – BjBlac B + inhibitor<br />
**[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[4nq7]], [[4tyt]] - BcBlac B + inhibitor<br />
**[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[4nq7]], [[4tyt]] - BcBlac B + inhibitor<br />
**[[3q6v]] – SfBlac B + glycerol <br />
**[[3q6v]] – SfBlac B + glycerol <br />
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
-
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]] – KpBlac B Ndm-1+ inhibitor<br />
+
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]] – KpBlac B Ndm-1+ inhibitor<br />
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
 +
**[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br />
 +
**[[5fqb]] - BcBlac B + inhibitor<br />
 +
**[[5evk]], [[5evd]], [[5evb]] - StmBlac B + inhibitor<br />
*'''β-lactamase class C'''
*'''β-lactamase class C'''
 +
**[[5f1g]] – EcBlac C<br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
-
**[[1zkj]] – Blac C – ''Enterobacter aerogenes''<br />
+
**[[1zkj]], [[5f1f]] – Blac C – ''Enterobacter aerogenes''<br />
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
**[[3w8k]] – KpBlac C<br />
**[[3w8k]] – KpBlac C<br />
Line 204: Line 262:
**[1rgy]] - CfBlac C + antibiotic <br />
**[1rgy]] - CfBlac C + antibiotic <br />
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
 +
**[[4wbg]] - KpBlac C + antibiotic<br />
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
**[[4ooy]] - PaBlac C + antibiotic<br />
**[[4ooy]] - PaBlac C + antibiotic<br />
Line 218: Line 277:
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
**[[1m6k]] – EcBlac D<br />
**[[1m6k]] – EcBlac D<br />
-
**[[4mll]] - KpBlac D Oxa-1 + oxacillin<br />
 
**[[3hbr]] – KpBlac D Oxa-48<br />
**[[3hbr]] – KpBlac D Oxa-48<br />
-
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br />
 
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
 +
**[[4zdx]] - AbBlac D Oxa-51<br />
 +
**[[4y0o]] - AbBlac D Oxa-58<br />
 +
**[[4s2l]] - EncBlac D Oxa-163<br />
 +
**[[5e2f]] – Blac D – ''Bacillus subtilis''<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
Line 231: Line 292:
**[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br />
**[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br />
**[[3isg]] – EcBlac D + inhibitor<br />
**[[3isg]] – EcBlac D + inhibitor<br />
 +
**[[4s2m]] - EncBlac D Oxa-163+ inhibitor<br />
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
-
**[[3znt]] - AbBlac D + inhibitor<br />
+
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br />
 +
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br />
 +
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br />
 +
**[[4x55]] - AbBlac D Oxa-225 (mutant) + antibiotic<br />
 +
[[4mll]] - KpBlac D Oxa-1 + antibiotic<br />
 +
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br />
 +
**[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]] - KpBlac D Oxa-48 + inhibitor<br />
*'''AmpC β-lactamase'''
*'''AmpC β-lactamase'''
Line 240: Line 308:
**[[1fcn]] – EcBlac (mutant) + substrate<br />
**[[1fcn]] – EcBlac (mutant) + substrate<br />
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
-
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]] - EcBlac + antibiotic<br />
+
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]] - EcBlac + antibiotic<br />
-
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]] - EcBlac + boronic acid inhibitor<br />
+
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]] - EcBlac + boronic acid inhibitor<br />
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]] - EcBlac + inhibitor<br />
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]] - EcBlac + inhibitor<br />
**[[4jxg]] – EcBlac + oxacillin<br />
**[[4jxg]] – EcBlac + oxacillin<br />
-
**[[1o07]] - EcBlac (mutant) + inhibitor<br />
+
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br />
 +
**[[4xux]] - EncBlac + boronic acid inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
-
**[[4hef]], [[4nk3]] - PaBlac + inhibitor<br />
+
**[[4hef]], [[4nk3]], [[4x68]] - PaBlac + inhibitor<br />
-
**[[4gzb]] – PaBlac<br />
+
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
**[[4net]] – AbBlac<br />
**[[4net]] – AbBlac<br />
 +
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
 +
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />
*'''Carbapenemase'''
*'''Carbapenemase'''
Line 255: Line 326:
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
-
**[[3rxw]], [[3rxx]] – KpBlac Kpc<br />
+
**[[3rxw]], [[3rxx]], [[2ov5]] – KpBlac Kpc<br />
-
**[[2ov5]] - KpBlac A Kpc<br />
+
**[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br />
 +
**[[4zbe]] - KpBlac Kpc-2 + inhibitor<br />
**[[4eqi]] – SfBlac Sfc-1<br />
**[[4eqi]] – SfBlac Sfc-1<br />
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
-
**[[4oh0]] - AbBlac OXA-58 <br />
+
**[[4oh0]], [[4z9q]] - AbBlac OXA-58 <br />
 +
**[[5boh]] - AbBlac OXA-58 (mutant)<br />
**[[1bue]] – EncBlac<br />
**[[1bue]] – EncBlac<br />
 +
**[[4tze]], [[4tzb]] - EcBlac Ndm-5<br />
 +
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
*'''Other β-lactamase'''
*'''Other β-lactamase'''
Line 270: Line 345:
**[[1gce]], [[1xx2]] - EncBlac <br />
**[[1gce]], [[1xx2]] - EncBlac <br />
**[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
**[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
 +
**[[5hfo]] - EcBlac Oxa-232<br />
**[[1dy6]] – SmBlac Sme-1<br />
**[[1dy6]] – SmBlac Sme-1<br />
**[[1fr1]], [[1fr6]] – CfBlac <br />
**[[1fr1]], [[1fr6]] – CfBlac <br />
Line 276: Line 352:
**[[4whi]] – MtBlac C terminal<br />
**[[4whi]] – MtBlac C terminal<br />
**[[4jlf]] - MtBlac (mutant)<br />
**[[4jlf]] - MtBlac (mutant)<br />
-
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
 
-
**[[4df6]] – MtBlac + inhibitor<br />
 
-
**[[4q8i]], [[4qb8]] – MtBlac + antibiotic<br />
 
**[[2jc7]], [[3g4p]] – AbBlac <br />
**[[2jc7]], [[3g4p]] – AbBlac <br />
**[[3byd]] – Blac – ''Klebsiella oxytoca''<br />
**[[3byd]] – Blac – ''Klebsiella oxytoca''<br />
Line 288: Line 361:
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br />
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br />
**[[3w4q]] – Blac – ''Burkholderia multivorans''<br />
**[[3w4q]] – Blac – ''Burkholderia multivorans''<br />
 +
**[[5ihv]] – Blac – ''Burkholderia ambifaria''<br />
 +
**[[5hx9]], [[5hw3]] – Blac – ''Burkholderia vietnamiensis''<br />
 +
**[[5evl]] – Blac – ''Chromobacterterium violaceum''<br />
 +
**[[5e43]] – Blac – ''Streptoporangium roseum''<br />
 +
**[[5e2e]] – Blac – ''Yersinia enterocolitica''<br />
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
**[[4k0x]] – AbBlac Oxa-23 <br />
**[[4k0x]] – AbBlac Oxa-23 <br />
Line 301: Line 379:
**[[1ga0]] - EncBlac + inhibitor<br />
**[[1ga0]] - EncBlac + inhibitor<br />
**[[1i2w]] – BlBlac + cifoxitin<br />
**[[1i2w]] – BlBlac + cifoxitin<br />
-
**[[3cg5]] – MtBlac + antibiotic<br />
+
**[[3cg5]], [[4q8i]], [[4qb8]] – MtBlac + antibiotic<br />
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
-
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]] – MtBlac + inhibitor<br />
+
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]] – MtBlac + inhibitor<br />
 +
**[[4x6t]], [[4qhc]] – MtBlac (mutant) + inhibitor<br />
 +
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br />
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br />

Revision as of 09:04, 22 March 2017

Class B β-lactamase Ndm-1 complex with Zn+2 (grey) (PDB code 3spu)

Drag the structure with the mouse to rotate

3D Structures of Beta-lactamase

Updated on 22-March-2017

4mll - KpBlac D Oxa-1 + antibiotic

References

  1. ↑ King D, Strynadka N. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance. Protein Sci. 2011 Sep;20(9):1484-91. doi: 10.1002/pro.697. Epub 2011 Aug, 2. PMID:21774017 doi:10.1002/pro.697

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

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