Casein kinase

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*CK1
*CK1
-
**[[2c47]] – hCK1-γ2 – human<br />
+
**[[5fqd]] - hCK1-α + DNA damage-binding protein + cereblon - human <br />
 +
**[[2c47]] – hCK1-γ2 <br />
**[[2chl]] - hCK1-γ3<br />
**[[2chl]] - hCK1-γ3<br />
**[[2cmw]] – hCK1-γ1 + inhibitor<br />
**[[2cmw]] – hCK1-γ1 + inhibitor<br />
**[[2izr]], [[2izs]], [[2izu]], [[2izt]], [[4g16]], [[4g17]], [[4hgl]], [[4hgs]] - hCK1-γ3 + inhibitor<br />
**[[2izr]], [[2izs]], [[2izu]], [[2izt]], [[4g16]], [[4g17]], [[4hgl]], [[4hgs]] - hCK1-γ3 + inhibitor<br />
-
**[[3uys]] – hCK1-δ<br />
+
**[[3uys]], [[5ih4]] – hCK1-δ<br />
-
**[[3uyt]], [[3uzp]], [[4hgt]], [[4hnf]], [[4kb8]], [[4kba]], [[4kbc]], [[4kbk]] – hCK1-δ + inhibitor<br />
+
**[[3uyt]], [[3uzp]], [[4hgt]], [[4hnf]], [[4kb8]], [[4kba]], [[4kbc]], [[4kbk]], [[5ih5]], [[5ih6]], [[4tn6]] – hCK1-δ + inhibitor<br />
**[[4tw9]], [[4twc]] – hCK1-δ (mutant) + inhibitor<br />
**[[4tw9]], [[4twc]] – hCK1-δ (mutant) + inhibitor<br />
**[[1cki]] – rCK1-δ (mutant) – rat<br />
**[[1cki]] – rCK1-δ (mutant) – rat<br />
Line 37: Line 38:
*CK2 catalytic subunit
*CK2 catalytic subunit
-
**[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]] - hCK2 α subunit <br />
+
**[[1pjk]], [[3at2]], [[3q04]], [[3qa0]], [[3war]], [[3ofm]] - hCK2 <br />
-
**[[1na7]], [[3fwq]], [[3juh]] - hCK2 α subunit (mutant)<br />
+
**[[1na7]], [[3fwq]], [[3juh]], [[5cu6]], [[5cvg]] - hCK2 (mutant)<br />
-
**[[3axw]], [[3r0t]], [[3u4u]] – hCK2 α subunit + inhibitor<br />
+
**[[3axw]], [[3r0t]], [[3u4u]] – hCK2 + inhibitor<br />
-
**[[3ofm]] - hCK2 α’ subunit <br />
+
**[[2r7i]] - rCK2 <br />
-
**[[2r7i]] - rCK2 α subunit <br />
+
**[[1lpu]], [[1lr4]], [[1jam]] - mCK2 <br />
-
**[[1lpu]], [[1lr4]], [[1jam]] - mCK2 α subunit <br />
+
*CK2 catalytic subunit binary complex
*CK2 catalytic subunit binary complex
-
**[[3u87]] – hCK2 α subunit + ATP analog<br />
+
**[[3u87]] – hCK2 + ATP analog<br />
-
**[[3q9w]], [[3q9x]] – hCK2 α subunit + emodin<br />
+
**[[3q9w]], [[3q9x]], [[3bqc]], [[3c13]] – hCK2 + emodin<br />
-
**[[3q9y]], [[3q9z]] – hCK2 α subunit + quinalizarin<br />
+
**[[3q9y]], [[3q9z]] – hCK2 + quinalizarin<br />
-
**[[3u9c]] – hCK2 α subunit + resorufin<br />
+
**[[3u9c]] – hCK2 + resorufin<br />
-
**[[2pvr]] - hCK2 α subunit + sulfate<br />
+
**[[2pvr]] - hCK2 + sulfate<br />
 +
**[[1j91]], [[4rlk]] - mCK2 + ATP competitive inhibitor - maize
-
**[[3bqc]], [[3c13]] - hCK2 α subunit + emodin
+
**[[1lp4]], [[1daw]], [[1day]] - mCK2 + Mg-AMPPNP
-
**[[1j91]], [[4rlk]] - mCK2 α subunit + ATP competitive inhibitor - maize
+
**[[3nsz]], [[3wow]] - hCK2 + AMPPN<br />
 +
**[[3w8l]] - hCK2 (mutant) + inositol hexakisphosphate<br />
 +
**[[4dgm]] - mCK2 + apigenin<br />
 +
**[[4dgn]] - mCK2 + luteolin<br />
 +
**[[4dgo]] - mCK2 + tyrphostin<br />
 +
**[[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 + inhibitor
-
**[[1lp4]], [[1daw]], [[1day]] - mCK2 α subunit + Mg-AMPPNP
+
**[[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]], [[4anm]], [[4grb]], [[4gub]], [[3axw]], [[3r0t]], [[3u4u]], [[3owj]], [[3owk]], [[3owl]], [[3wik]], [[3wil]], [[5cqw]], [[5cqu]], [[4kwp]], [[4rll]], [[5m44]], [[5m4c]], [[5m4f]], [[5m4i]], [[5h8b]], [[5h8e]], [[5h8g]], [[5b0x]], [[4ub7]], [[4uba]] - hCK2 + inhibitor<br />
-
 
+
**[[5m4u]], [[5m56]], [[5clp]], [[5cs6]], [[5csh]], [[5csp]], [[5csv]], [[5ct0]], [[5ctp]], [[5cu0]], [[5cu2]], [[5cu3]], [[5cu4]], [[5cvf]], [[5cx9]] - hCK2 (mutant) + inhibitor<br />
-
**[[3nsz]], [[3wow]] - hCK2 α subunit + AMPPN<br />
+
**[[4fbx]] - hCK2 + polypeptide inhibitor<br />
-
**[[3w8l]] - hCK2 α subunit (mutant) + inositol hexakisphosphate<br />
+
**[[4ib5]] - hCK2 + hCK2 β polypeptide <br />
-
**[[4dgm]] - mCK2 α subunit + apigenin<br />
+
**[[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 (mutant) + inhibitor<br />
-
**[[4dgn]] - mCK2 α subunit + luteolin<br />
+
**[[1f0q]], [[3pzh]] – mCK2 + emodin<br />
-
**[[4dgo]] - mCK2 α subunit + tyrphostin<br />
+
**[[1zoe]], [[1zog]], [[1zoh]] – mCK2 + TBB derivative<br />
-
**[[1m2p]], [[1m2q]], [[1m2r]], [[1om1]], [[2oxd]], [[2oxx]], [[2oxy]], [[2qc6]], [[2pvh]], [[3fl5]], [[3kxg]], [[3kxh]], [[3kxm]], [[3kxn]], [[3pvg]], [[3pwd]] - mCK2 α subunit + inhibitor
+
**[[4fi1]], [[4mwh]] - yCK2 + ATP<br />
-
 
+
**[[4jqe]] - yCK2 + AMPPN<br />
-
**[[3e3b]], [[2zjw]], [[3h30]], [[3mb6]], [[3mb7]], [[3nga]], [[3rps]], [[3pe1]], [[3pe2]], [[3amy]], [[3at3]], [[3at4]], [[4anm]], [[4grb]], [[4gub]], [[3axw]], [[3r0t]], [[3u4u]], [[3owj]], [[3owk]], [[3owl]], [[3wik]], [[3wil]], [[5cqw]], [[5cqu]], [[4kwp]], [[4rll]] - hCK2 α subunit + inhibitor<br />
+
**[[4jr7]], [[4lfi]] - yCK2 + GMPPNP<br />
-
**[[4fbx]] - hCK2 α subunit + polypeptide inhibitor<br />
+
-
**[[4ib5]] - hCK2 α subunit + hCK2 β polypeptide <br />
+
-
**[[2pvh]], [[2pvj]], [[2pvk]], [[2pvl]], [[2pvm]], [[2pvn]], [[3be9]] - mCK2 α subunit (mutant) + inhibitor<br />
+
-
**[[1f0q]], [[3pzh]] – mCK2 α subunit + emodin<br />
+
-
**[[1zoe]], [[1zog]], [[1zoh]] – mCK2 α subunit + TBB derivative<br />
+
-
**[[4fi1]], [[4mwh]] - yCK2 α subunit + ATP<br />
+
-
**[[4jqe]] - yCK2 α subunit + AMPPN<br />
+
-
**[[4jr7]], [[4lfi]] - yCK2 α subunit + GMPPNP<br />
+
*CK2 regulatory subunit
*CK2 regulatory subunit
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**[[4nh1]] - hCK2 α subunit + β subunit (mutant)<br />
**[[4nh1]] - hCK2 α subunit + β subunit (mutant)<br />
**[[1ds5]] - mCK2 α subunit + β subunit peptide
**[[1ds5]] - mCK2 α subunit + β subunit peptide
 +
 +
*Golgi casein kinase
 +
 +
**[[4kqb]], [[4kqa]] - GCK – nematode<br />
 +
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:23, 28 March 2017

Human casein kinase 1 γ3 complex with inhibitor (PDB code 4g16)

Drag the structure with the mouse to rotate

3D Structures of casein kinase

Updated on 28-March-2017

References

  1. ↑ Eide EJ, Virshup DM. Casein kinase I: another cog in the circadian clockworks. Chronobiol Int. 2001 May;18(3):389-98. PMID:11475410
  2. ↑ Pinna LA, Meggio F. Protein kinase CK2 ("casein kinase-2") and its implication in cell division and proliferation. Prog Cell Cycle Res. 1997;3:77-97. PMID:9552408
  3. ↑ Hua Z, Huang X, Bregman H, Chakka N, DiMauro EF, Doherty EM, Goldstein J, Gunaydin H, Huang H, Mercede S, Newcomb J, Patel VF, Turci SM, Yan J, Wilson C, Martin MW. 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1gamma) inhibitors. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5392-5. doi: 10.1016/j.bmcl.2012.07.046. , Epub 2012 Jul 20. PMID:22877629 doi:10.1016/j.bmcl.2012.07.046

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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