Major capsid protein L1
From Proteopedia
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== Introduction== | == Introduction== | ||
| - | Gardasil 9 is a recombinant vaccine for the human papillomavirus and protects from the 9 most common forms that are known to cause the majority of HPV-related diseases and cancer. These types are 6, 11, 16, 18, 31, 33, 45, 52, and 58. HPVs are the causative agents of human neoplasia such as warts and cancers <ref>DOI 10.1016/j.antiviral.2016.03.016</ref>. The HPV vaccine is recommended for children ages 11 to 12 and is intended for females ages 9-25 and protects against cervical cancer, vulvar and vaginal cancer, anal cancer, and genital warts. The vaccine is also intended for males ages 9-26 and protects against anal cancer and genital warts <ref>https://www.gardasil9.com</ref>. Gardasil vaccine is made up of proteins that resemble the ones on the outside of an actual human papillomavirust <ref>http://www.hpvvaccine.org.au/the-hpv-vaccine/how-does-it-work.aspx</ref>.The main ingredient in Gardasil 9 is the <scene name='74/746002/L1_pentamer_structure/1'>L1 major capsid protein</scene> <ref name="L1">https://www.medicines.org.uk/emc/medicine/19016</ref>. | + | Gardasil 9 is a recombinant vaccine for the human papillomavirus and protects from the 9 most common forms that are known to cause the majority of HPV-related diseases and cancer. These types are 6, 11, 16, 18, 31, 33, 45, 52, and 58. HPVs are the causative agents of human neoplasia such as warts and cancers <ref>DOI 10.1016/j.antiviral.2016.03.016</ref>. The HPV vaccine is recommended for children ages 11 to 12 and is intended for females ages 9-25 and protects against cervical cancer, vulvar and vaginal cancer, anal cancer, and genital warts. The vaccine is also intended for males ages 9-26 and protects against anal cancer and genital warts <ref>https://www.gardasil9.com</ref>. Gardasil vaccine is made up of proteins that resemble the ones on the outside of an actual human papillomavirust <ref name="aus">http://www.hpvvaccine.org.au/the-hpv-vaccine/how-does-it-work.aspx</ref>.The main ingredient in Gardasil 9 is the <scene name='74/746002/L1_pentamer_structure/1'>L1 major capsid protein</scene> <ref name="L1">https://www.medicines.org.uk/emc/medicine/19016</ref>. |
== Function == | == Function == | ||
| - | Gardasil mimics the HPV virus, but it does not contain any viral DNA which removes any chance of infection of the HPV virus. This vaccine allows the body to create antibodies to HPV in order to be able to remove the virus if it is introduced in the body. Since the L1 protein is the main structural component of HPV and Gardasil, Gardasil can use this protein to remove HPV from the infected cells <ref | + | Gardasil mimics the HPV virus, but it does not contain any viral DNA which removes any chance of infection of the HPV virus. This vaccine allows the body to create antibodies to HPV in order to be able to remove the virus if it is introduced in the body. Since the L1 protein is the main structural component of HPV and Gardasil, Gardasil can use this protein to remove HPV from the infected cells <ref name="aus" />. |
== Structural Highlights== | == Structural Highlights== | ||
Revision as of 00:09, 15 November 2016
Gardasil 9
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Zhai L, Tumban E. Gardasil-9: A global survey of projected efficacy. Antiviral Res. 2016 Jun;130:101-9. doi: 10.1016/j.antiviral.2016.03.016. Epub, 2016 Apr 1. PMID:27040313 doi:http://dx.doi.org/10.1016/j.antiviral.2016.03.016
- ↑ https://www.gardasil9.com
- ↑ 5.0 5.1 http://www.hpvvaccine.org.au/the-hpv-vaccine/how-does-it-work.aspx
- ↑ 6.0 6.1 https://www.medicines.org.uk/emc/medicine/19016
- ↑ doi: https://dx.doi.org/10.1128/JVI.77.8.4818-4826.2003
- ↑ http://www.uniprot.org/uniprot/P03101
Proteopedia Page Contributors and Editors (what is this?)
Morgan Smith, Michal Harel, Jessica Troutman., Maximillia Jackson., Jaime Prilusky
