Ribavirin
From Proteopedia
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Ribavirin was first synthesized in 1970 by ICN Pharmaceuticals (now “Valent International Pharmaceuticals”). In 1986, its first major use was the treatment of RSV (respiratory syncitial virus) infections in pediatric patients. Since its FDA approval in 1998, it has primarily been used as a component in treating Hepatitis C. The treatment was modified and approved in 2002 by the FDA by combining it with interferon alfa2b. (from “Gish” in general info) | Ribavirin was first synthesized in 1970 by ICN Pharmaceuticals (now “Valent International Pharmaceuticals”). In 1986, its first major use was the treatment of RSV (respiratory syncitial virus) infections in pediatric patients. Since its FDA approval in 1998, it has primarily been used as a component in treating Hepatitis C. The treatment was modified and approved in 2002 by the FDA by combining it with interferon alfa2b. (from “Gish” in general info) | ||
| - | == Function == | + | == Structure & Function == |
| - | While | + | |
| + | While the main function of Ribavirin is to treat Hepatitis C and RSV, Ribavirin alone is not enough to treat these diseases and is commonly combined with interferon alfa2b. Ribavirin contains antiviral activity which inhibits DNA/RNA synthesis.The structure of Ribavirin resembles the structure of the nucleoside guanosine. Like guanosine, ribavirin is also water soluble and is able to mimic other purines as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that it’s heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. It’s structural similarity to the common nucleoside guanosine may suggest how the drug can inhibit DNA/RNA synthesis through purine mimicry. | ||
== Disease == | == Disease == | ||
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== Mechanism == | == Mechanism == | ||
| - | == Structural highlights == | ||
| - | The structure of ribavirin resembles the structure of the nucleoside guanosine. Like guanosine, ribavirin is also water soluble and is able to mimic other purines as well. However, a key difference between the structure of ribavirin and the purine nucleosides is that it’s heterocyclic base contains only one ring, as opposed to purines which have two. Despite this, it is able to go through similar mechanisms as that of nucleosides such as phosphorylating into a triphosphate. | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 01:54, 16 November 2016
1-β-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide (http://www.rxlist.com/rebetol-drug.htm)
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References
Chung, R.T., Gale, M.J., Polyak, S.J., Lemon, S.M., Liang, T.J., & Hoofnagle, J.H. (2008). Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop. Hepatology, 47 (1), 306-320. doi: 10.1002/hep.22070
Proteopedia Page Contributors and Editors (what is this?)
Jamie Costa, Edmond R Atalla, Katherine Reynolds, Taylor H. Derby, Shannon Shaughnessy, Alexander Berchansky
