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Exonuclease

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Line 75: Line 75:
**[[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br />
**[[2jea]], [[2je6]], [[2jeb]] - SsExN-I (mutant) + ExN-II + RNA-binding protein 1<br />
**[[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) - yeast<br />
**[[2hbj]], [[2hbk]], [[2hbl]], [[2hbm]] – yExN Rrp6 (mutant) - yeast<br />
 +
**[[5c0y]] - yExN Rrp6 (mutant) + RNA<br />
**[[2ja9]] – yExN Rrp40<br />
**[[2ja9]] – yExN Rrp40<br />
**[[2vnu]] – yExN Rrp44 + DNA<br />
**[[2vnu]] – yExN Rrp44 + DNA<br />
Line 82: Line 83:
**[[4wfc]] - yExN Rrp6 + Lrp1<br />
**[[4wfc]] - yExN Rrp6 + Lrp1<br />
**[[4wfd]] - yExN Rrp6 + Lrp1 + Dob1<br />
**[[4wfd]] - yExN Rrp6 + Lrp1 + Dob1<br />
-
**[[4ifd]], [[4oo1]] - yExN Rrp6, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4, Rrp6, Ski6, Dis3 + RNA<br />
+
**[[4ifd]], [[4oo1]], [[5k36]], [[5c0x]] - yExN Rrp6, Rrp45, Rrp42, Rrp40, Prp43, Rrp46, Mtr3, Csl4, Rrp4, Rrp6, Ski6, Dis3 + RNA<br />
 +
**[[5jea]] - yExN Rrp45, Rrp42, Rrp43, Rrp40, Rrp46, Mtr3, Csl4, Rrp4, Ski6, Dis3 + endolysin + RNA<br />
 +
**[[5c0w]] - yExN Rrp45, Rrp42, Rrp43, Rrp40, Rrp46, Mtr3, Csl4, Rrp4, Ski6, Dis3 + Lrp1 + RNA<br />
 +
**[[5g06]] - yExN Rrp45, Rrp42, Rrp43, Rrp40, Rrp46, Mtr3, Csl4, Rrp4, Ski6, Dis3 + endolysin <br />
-
*Other ExN
+
*ssDNA-specific ExN
 +
 
 +
**[[5ght]] – TkExN – ''Thermococcus kodakarensis''<br />
 +
**[[5ghs]], [[5ghr]] – TkExN + polypeptide<br />
 +
**[[5f54]] – DrExN + dTMP<br />
 +
**[[5f55]] – DrExN + DNA<br />
 +
**[[5f56]] – DrExN + DNA + polypeptide<br />
 +
 
 +
*3-5 ExN phoexo I
 +
 
 +
**[[4yor]], [[4yot]], [[4you]] – PhExN – ''Pyrococcus horikoshii''<br />
 +
**[[4yov]], [[4yow]], [[4yox]], [[4yoy]] – PhExN (mutant) + DNA<br />
 +
 
 +
*ExN Trex
-
**[[1ir6]], [[2zxo]], [[2zxp]], [[2zxr]] – ExN Recj – ''Thermus thermophiles''<br />
 
-
**[[1w0h]] – hExn Eri1 nuclease domain <br />
 
-
**[[1zbu]] - hExn Eri1<br />
 
-
**[[1zbh]] - hExn Eri1 (mutant) + DNA<br />
 
**[[1y97]] – hExN Trex2<br />
**[[1y97]] – hExN Trex2<br />
-
**[[5aho]] – hExN Apollo<br />
 
**[[2o4g]] - mExN Trex1 + nucleotide – mouse<br />
**[[2o4g]] - mExN Trex1 + nucleotide – mouse<br />
**[[3mxj]] - mExN Trex1<br />
**[[3mxj]] - mExN Trex1<br />
**[[2o4i]], [[3mxi]], [[3mxm]], [[3u3y]], [[3u6f]] - mExN Trex1 (mutant) + polynucleotide<br />
**[[2o4i]], [[3mxi]], [[3mxm]], [[3u3y]], [[3u6f]] - mExN Trex1 (mutant) + polynucleotide<br />
**[[2oa8]] - mExN Trex1 + DNA<br />
**[[2oa8]] - mExN Trex1 + DNA<br />
 +
**[[4ynq]] - mExN Trex1 (mutant) + DNA<br />
**[[3b6o]], [[3b6p]] - mExN Trex1 + ion inhibitor<br />
**[[3b6o]], [[3b6p]] - mExN Trex1 + ion inhibitor<br />
 +
 +
*Other ExN
 +
 +
**[[1ir6]], [[2zxo]], [[2zxp]], [[2zxr]] – ExN Recj – ''Thermus thermophiles''<br />
 +
**[[1w0h]] – hExn Eri1 nuclease domain <br />
 +
**[[1zbu]] - hExn Eri1<br />
 +
**[[1zbh]] - hExn Eri1 (mutant) + DNA<br />
 +
**[[5aho]] – hExN Apollo<br />
**[[2w45]] – H4ExN alkaline - Herpesvirus 4<br />
**[[2w45]] – H4ExN alkaline - Herpesvirus 4<br />
**[[2w4b]] - H4ExN alkaline (mutant)<br />
**[[2w4b]] - H4ExN alkaline (mutant)<br />

Revision as of 09:41, 10 May 2017

E. coli exonuclease I complex with phosphate, glycerol and Mg+2 ion (PDB code 1fxx)

Drag the structure with the mouse to rotate

3D Structures of exonuclease

Updated on 10-May-2017

References

  1. Mukherjee D, Fritz DT, Kilpatrick WJ, Gao M, Wilusz J. Analysis of RNA exonucleolytic activities in cellular extracts. Methods Mol Biol. 2004;257:193-212. PMID:14770007 doi:http://dx.doi.org/10.1385/1-59259-750-5:193
  2. Breyer WA, Matthews BW. Structure of Escherichia coli exonuclease I suggests how processivity is achieved. Nat Struct Biol. 2000 Dec;7(12):1125-8. PMID:11101894 doi:10.1038/81978

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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