Galactosidase
From Proteopedia
(Difference between revisions)
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**[[3lx9]], [[3lxa]], [[3lxb]], [[3lxc]], [[3tv8]] - hAgal A (mutant) – human<br /> | **[[3lx9]], [[3lxa]], [[3lxb]], [[3lxc]], [[3tv8]] - hAgal A (mutant) – human<br /> | ||
**[[3hg2]], [[3gxn]], [[1r46]], [[1r47]], [[3s5y]], [[3s5z]] – hAgal A<br /> | **[[3hg2]], [[3gxn]], [[1r46]], [[1r47]], [[3s5y]], [[3s5z]] – hAgal A<br /> | ||
| - | **[[1zy9]] – TmAgal – ''Thermotoga maritima''<br /> | + | **[[1zy9]], [[5m0x]] – TmAgal – ''Thermotoga maritima''<br /> |
**[[3h53]] - hAgal B (mutant)<br /> | **[[3h53]] - hAgal B (mutant)<br /> | ||
**[[3a24]] – BtAgal – ''Bacterioides thetaiotamicron''<br /> | **[[3a24]] – BtAgal – ''Bacterioides thetaiotamicron''<br /> | ||
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**[[2xn0]], [[2xn1]] – LaAgal – ''Lactobacillus acidophilus''<br /> | **[[2xn0]], [[2xn1]] – LaAgal – ''Lactobacillus acidophilus''<br /> | ||
**[[4fnp]], [[4ojy]] – GsAgal (mutant) – ''Geobacillus stearothermophilus''<br /> | **[[4fnp]], [[4ojy]] – GsAgal (mutant) – ''Geobacillus stearothermophilus''<br /> | ||
| - | **[[4fnq]], [[4fnr]], [[4oif]] – GsAgal | + | **[[4fnq]], [[4fnr]], [[4oif]] – GsAgal<br /> |
| + | **[[4xpo]] - PsBgal – ''Pedobacter saltans'' <br /> | ||
| + | **[[4xpr]] - PsAgal (mutant)<br /> | ||
*''α-galactosidase binary complex'' | *''α-galactosidase binary complex'' | ||
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**[[1t0o]] – HjAgal + galactose<br /> | **[[1t0o]] – HjAgal + galactose<br /> | ||
**[[2xn2]] - LaAgal + galactose<br /> | **[[2xn2]] - LaAgal + galactose<br /> | ||
| + | **[[4xpp]] - PsAgal + galactose<br /> | ||
| + | **[[4xpq]] - PsAgal + fucose<br /> | ||
| + | **[[4xps]] - PsAgal (mutant) + galactopyranoside derivative<br /> | ||
**[[4fns]] - GsAgal (mutant) + jirimycin derivative<br /> | **[[4fns]] - GsAgal (mutant) + jirimycin derivative<br /> | ||
| - | **[[4fnt]], [[4fnu]] – GsAgal + galactoside | + | **[[4fnt]], [[4fnu]] – GsAgal + galactoside<br /> |
| + | **[[5e1q]] - BtAgal + Gal-Lac<br /> | ||
| + | **[[5m12]], [[5m16]], [[5m1i]] - TmAgal + sugar<br /> | ||
*β-Galactosidase | *β-Galactosidase | ||
**[[3og2]] – TrBgal – ''Trichoderma reesei''<br /> | **[[3og2]] – TrBgal – ''Trichoderma reesei''<br /> | ||
| - | **[[3muy]], [[3i3e]], [[3iap]], [[3iaq]], [[3dyp]], [[1px3]], [[3sep]], [[3t0a]], [[3t2o]], [[3vd3]], [[3vd5]], [[3vda]], [[4duv]] – EcBgal (mutant) – ''Escherichia coli''<br /> | + | **[[3muy]], [[3i3e]], [[3iap]], [[3iaq]], [[3dym]], [[3dyp]], [[1px3]], [[3sep]], [[3t0a]], [[3t2o]], [[3vd3]], [[3vd5]], [[3vda]], [[4duv]] – EcBgal (mutant) – ''Escherichia coli''<br /> |
**[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal<br /> | **[[1hn1]], [[1dp0]], [[1f4a]], [[1f4h]], [[4v41]], [[4v40]], [[4ttg]] - EcBgal<br /> | ||
**[[3j7h]] – EcBgal – cryo EM<br /> | **[[3j7h]] – EcBgal – cryo EM<br /> | ||
| - | **[[3dec]], [[3d3a]], [[3bga]] – BtBgal<br /> | + | **[[3dec]], [[3d3a]], [[3bga]], [[5mt2]], [[5mui]], [[5muj]] – BtBgal<br /> |
**[[1yq2]] - Bgal (mutant) – Arthrobacter<br /> | **[[1yq2]] - Bgal (mutant) – Arthrobacter<br /> | ||
| - | **[[1uwi]], [[4eam]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br /> | + | **[[1uwi]], [[4eam]], [[5i3d]] - SsBgal (mutant) - ''Sulfolobus solfataricus''<br /> |
| - | **[[1uwq]], [[ | + | **[[1uwq]], [[1gow]] – SsBgal<br /> |
**[[1kwg]] – TtBgal – ''Thermus thermophilus''<br /> | **[[1kwg]] – TtBgal – ''Thermus thermophilus''<br /> | ||
**[[1tg7]] – PeBgal – ''Penicillium''<br /> | **[[1tg7]] – PeBgal – ''Penicillium''<br /> | ||
| - | **[[3tts]] – BcBgal – ''Bacillus circulans''<br /> | + | **[[3tts]], [[4mad]] – BcBgal – ''Bacillus circulans''<br /> |
| + | **[[4ypj]] - BcBgal (mutant) <br /> | ||
**[[4ha3]], [[4ha4]] – Bgal – ''Acidilobus saccharovorans''<br /> | **[[4ha3]], [[4ha4]] – Bgal – ''Acidilobus saccharovorans''<br /> | ||
**[[3w5f]] – toBgal – tomato<br /> | **[[3w5f]] – toBgal – tomato<br /> | ||
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**[[4uoq]] - BaBgal (mutant) – ''Bifidobacterium animalis''<br /> | **[[4uoq]] - BaBgal (mutant) – ''Bifidobacterium animalis''<br /> | ||
**[[3ob8]], [[3oba]] – Bgal – ''Kluyveromyces lactis''<br /> | **[[3ob8]], [[3oba]] – Bgal – ''Kluyveromyces lactis''<br /> | ||
| + | **[[5dfa]] - GsBgal (mutant) <br /> | ||
| + | **[[5dmy]] - BbBgal – ''Bifidobacterium bifidum''<br /> | ||
| + | **[[5e9a]] - Bgal - ''Rahnella''<br /> | ||
| + | **[[5euv]] - ParBgal - ''Paracoccus''<br /> | ||
| + | **[[5iaz]] - rBgal C-terminal - NMR<br /> | ||
| + | **[[5ifp]] - Bgal – ''Aspergillus niger''<br /> | ||
*''β-Galactosidase binary complex with galactose'' | *''β-Galactosidase binary complex with galactose'' | ||
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**[[4uni]] - BaBgal + galactose <br /> | **[[4uni]] - BaBgal + galactose <br /> | ||
**[[4uoz]] - BaBgal (mutant) + galactose <br /> | **[[4uoz]] - BaBgal (mutant) + galactose <br /> | ||
| + | **[[4ucf]], [[4uzs]] - BbBgal + galactose <br /> | ||
| + | **[[5ldr]] - ParBgal + galactose <br /> | ||
*''β-Galactosidase other complexes'' | *''β-Galactosidase other complexes'' | ||
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**[[3ogv]] – TrBgal + inhibitor<br /> | **[[3ogv]] – TrBgal + inhibitor<br /> | ||
**[[2ceq]], [[1uwr]], [[1uws]], [[1uwt]], [[1uwu]], [[2cer]] - SsBgal + inhibitor<br /> | **[[2ceq]], [[1uwr]], [[1uws]], [[1uwt]], [[1uwu]], [[2cer]] - SsBgal + inhibitor<br /> | ||
| - | **[[4ean]] – SsBgal + indole<br /> | + | **[[4ean]], [[5ixe]] – SsBgal + indole derivative<br /> |
**[[3muz]], [[3i3d]], [[3dyo]], [[1px4]], [[1jyx]], [[3t08]], [[3t0b]], [[3t2p]], [[3vd4]], [[3vd9]], [[3vdc]]- EcBgal (mutant) + IPTG<br /> | **[[3muz]], [[3i3d]], [[3dyo]], [[1px4]], [[1jyx]], [[3t08]], [[3t0b]], [[3t2p]], [[3vd4]], [[3vd9]], [[3vdc]]- EcBgal (mutant) + IPTG<br /> | ||
**[[3mv0]], [[3i3b]], [[3czj]], [[4v45]], [[1jz2]], [[1jz3]], [[1jz4]], [[1jz5]], [[1jz6]] - EcBgal (mutant) + intermediate<br /> | **[[3mv0]], [[3i3b]], [[3czj]], [[4v45]], [[1jz2]], [[1jz3]], [[1jz4]], [[1jz5]], [[1jz6]] - EcBgal (mutant) + intermediate<br /> | ||
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**[[1jyn]], [[4v44]], [[1jz8]] - EcBgal (mutant) + lactose derivative<br /> | **[[1jyn]], [[4v44]], [[1jz8]] - EcBgal (mutant) + lactose derivative<br /> | ||
**[[1jyn]], [[1jyw]], [[1jyv]] - EcBgal (mutant) + substrate<br /> | **[[1jyn]], [[1jyw]], [[1jyv]] - EcBgal (mutant) + substrate<br /> | ||
| + | **[[5a1a]] - EcBgal + inhibitor – Cryo-EM<br /> | ||
**[[1jz6]] - EcBgal (mutant) + inhibitor<br /> | **[[1jz6]] - EcBgal (mutant) + inhibitor<br /> | ||
**[[4duw]] - EcBgal (mutant) + allolactose<br /> | **[[4duw]] - EcBgal (mutant) + allolactose<br /> | ||
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**[[3wez]] - hBgal + NOEV<br /> | **[[3wez]] - hBgal + NOEV<br /> | ||
**[[3wf0]], [[3wf1]] - hBgal + pyrimidine derivative<br /> | **[[3wf0]], [[3wf1]] - hBgal + pyrimidine derivative<br /> | ||
| + | **[[3wf4]] - hBgal (mutant) + pyridine derivative<br /> | ||
**[[3wf2]] - hBgal + piperidine derivative<br /> | **[[3wf2]] - hBgal + piperidine derivative<br /> | ||
**[[4cu7]] - SpBgal catalytic module + galacto-isofagomine<br /> | **[[4cu7]] - SpBgal catalytic module + galacto-isofagomine<br /> | ||
Revision as of 09:48, 23 May 2017
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3D Structures of Galactosidase
Updated on 23-May-2017
References
- ↑ Garman SC, Garboczi DN. The molecular defect leading to Fabry disease: structure of human alpha-galactosidase. J Mol Biol. 2004 Mar 19;337(2):319-35. PMID:15003450 doi:10.1016/j.jmb.2004.01.035
- ↑ Jacobson RH, Zhang XJ, DuBose RF, Matthews BW. Three-dimensional structure of beta-galactosidase from E. coli. Nature. 1994 Jun 30;369(6483):761-6. PMID:8008071 doi:http://dx.doi.org/10.1038/369761a08015589
- ↑ Kint JA. Fabry's disease: alpha-galactosidase deficiency. Science. 1970 Feb 27;167(3922):1268-9. PMID:5411915
- ↑ Morrone A, Bardelli T, Donati MA, Giorgi M, Di Rocco M, Gatti R, Parini R, Ricci R, Taddeucci G, D'Azzo A, Zammarchi E. beta-galactosidase gene mutations affecting the lysosomal enzyme and the elastin-binding protein in GM1-gangliosidosis patients with cardiac involvement. Hum Mutat. 2000;15(4):354-66. PMID:10737981 doi:<354::AID-HUMU8>3.0.CO;2-L 10.1002/(SICI)1098-1004(200004)15:4<354::AID-HUMU8>3.0.CO;2-L
- ↑ Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J Mol Biol. 2002 Sep 6;322(1):79-91. PMID:12215416
- Created with the participation of Wayne Decatur.
