Insulin receptor

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Line 21: Line 21:
[[1i44]], [[1p14]] – hIR TK domain (mutant) <br />
[[1i44]], [[1p14]] – hIR TK domain (mutant) <br />
[[2hr7]] – hIR domains 1-3<br />
[[2hr7]] – hIR domains 1-3<br />
 +
[[4xst]] – hIR  L1-CR domains <br />
[[2mfr]] – hIR transmembrane domain - NMR<br />
[[2mfr]] – hIR transmembrane domain - NMR<br />
[[4xlv]] - hIR TK domain (mutant) + ATP derivative<br />
[[4xlv]] - hIR TK domain (mutant) + ATP derivative<br />
Line 27: Line 28:
[[3bu3]] - hIR TK domain + peptide<br />
[[3bu3]] - hIR TK domain + peptide<br />
[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br />
[[1gag]], [[2z8c]] - hIR TK domain (mutant) + peptide<br />
-
[[3ekk]], [[3ekn]], [[4ibm]] - hIR TK domain (mutant) + inhibitor<br />
+
[[3ekk]], [[3ekn]], [[4ibm]], [[5hhw]] - hIR TK domain (mutant) + inhibitor<br />
-
[[3eta]] - hIR TK domain + inhibitor<br />
+
[[3eta]], [[5e1s]] - hIR TK domain + inhibitor<br />
[[4zxb]] - hIR ectodomain (mutant) + antibody<br />
[[4zxb]] - hIR ectodomain (mutant) + antibody<br />
[[2auh]] – hIR TK domain + growth factor receptor-bound protein 14<br />
[[2auh]] – hIR TK domain + growth factor receptor-bound protein 14<br />

Revision as of 09:11, 19 June 2017

Structure of human insulin receptor tyrosine kinase catalytic domain complex with insulin receptor substrate 2 peptide (cyan), Mg+2 ion (green) and ATP (PDB entry 3bu5)

Drag the structure with the mouse to rotate

3D structures of insulin receptor

1irk – hIR TK domain – human
1i44, 1p14 – hIR TK domain (mutant)
2hr7 – hIR domains 1-3
4xst – hIR  L1-CR domains
2mfr – hIR transmembrane domain - NMR
4xlv - hIR TK domain (mutant) + ATP derivative
1ir3 - hIR TK domain (mutant) + ATP analog + peptide
3bu5, 3bu6 - hIR TK domain + ATP + peptide
3bu3 - hIR TK domain + peptide
1gag, 2z8c - hIR TK domain (mutant) + peptide
3ekk, 3ekn, 4ibm, 5hhw - hIR TK domain (mutant) + inhibitor
3eta, 5e1s - hIR TK domain + inhibitor
4zxb - hIR ectodomain (mutant) + antibody
2auh – hIR TK domain + growth factor receptor-bound protein 14
2b4s - hIR TK domain + tyrosine-protein phosphatase
1rqq – hIR TK domain (mutant) + adaptor protein PS

References

  1. ↑ Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb;266(2 Pt 1):C319-34. PMID:8141246
  2. ↑ Frasca F, Pandini G, Sciacca L, Pezzino V, Squatrito S, Belfiore A, Vigneri R. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch Physiol Biochem. 2008 Feb;114(1):23-37. doi: 10.1080/13813450801969715 . PMID:18465356 doi:http://dx.doi.org/10.1080/13813450801969715
  3. ↑ Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat Struct Mol Biol. 2008 Mar;15(3):251-8. Epub 2008 Feb 17. PMID:18278056 doi:10.1038/nsmb.1388
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