Kinesin
From Proteopedia
(Difference between revisions)
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**[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | **[[2zfi]], [[2zfj]], [[2zfk]], [[2zfl]], [[2zfm]] – mKIF1A – mouse<br /> | ||
| + | **[[3wrd]] – mKIF5C<br /> | ||
**[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br /> | **[[2vvg]] – KIF2 MD – ''Giardia intestinalis''<br /> | ||
**[[2g1l]] - hKIF1C FHA domain<br /> | **[[2g1l]] - hKIF1C FHA domain<br /> | ||
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**[[2cow]] – hKIF13B CAP-gly domain – NMR<br /> | **[[2cow]] – hKIF13B CAP-gly domain – NMR<br /> | ||
**[[1bg2]] – hKIF MD<br /> | **[[1bg2]] – hKIF MD<br /> | ||
| + | **[[5lt3]], [[5lt4]] – hKIF MD (mutant) <br /> | ||
**[[3kin]], [[2kin]] – rKIF MD - rat<br /> | **[[3kin]], [[2kin]] – rKIF MD - rat<br /> | ||
**[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br /> | **[[1ry6]] – KIF MD – ''Plasmodium falciparum''<br /> | ||
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**[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br /> | **[[1v8k]] - mKIF2C MD+Mg-AMPPNP<br /> | ||
**[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br /> | **[[3zfc]], [[3zfd]] – mKIF4 MD+Mg-AMPPNP<br /> | ||
| + | **[[3x2t]] – mKIF5C + ADP<br /> | ||
**[[2cjo]] – hKIF13+inhibitor 30<br /> | **[[2cjo]] – hKIF13+inhibitor 30<br /> | ||
**[[3nwn]] – hKIF9+ADP<br /> | **[[3nwn]] – hKIF9+ADP<br /> | ||
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**[[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br /> | **[[1ia0]] – KIF1A MD+Tubulin A+Tubulin B+ATP - pig<br /> | ||
**[[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br /> | **[[3edl]] – cKIF MD+ Tubulin A+Tubulin B – EM<br /> | ||
| - | **[[4hna]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br /> | + | **[[4hna]], [[4lnu]] – hKIF1 + Tubulin A + Tubulin B + designed ankyrin repeat protein + Mg-ADP + GDP + GTP + AlF4<br /> |
| + | **[[4uxy]] – hKIF1 MD + Tubulin A + Tubulin B + GDP + GTP – Cryo EM<br /> | ||
**[[2p4n]] – hKIF+ Tubulin A+Tubulin B – EM docking<br /> | **[[2p4n]] – hKIF+ Tubulin A+Tubulin B – EM docking<br /> | ||
**[[1mkj]] – hKIF MD+docked FNL<br /> | **[[1mkj]] – hKIF MD+docked FNL<br /> | ||
**[[1n6m]] – DmKIF MD+FNL<br /> | **[[1n6m]] – DmKIF MD+FNL<br /> | ||
| - | **[[4atx]] - rKIF MD+ Tubulin A+Tubulin B – EM | + | **[[4atx]] - rKIF MD+ Tubulin A+Tubulin B – Cryo EM<br /> |
| + | **[[3j6h]] – mKIF5C MD+Mg-GTP + G2P + tubulin α-1A and β<br /> | ||
| + | **[[3j8x]], [[3j8y]] – mKIF5C MD+ GTP + GDP + tubulin a-1A and b<br /> | ||
*Kinesin light chain (KLC) | *Kinesin light chain (KLC) | ||
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**[[3edt]] – hKLC2<br /> | **[[3edt]] – hKLC2<br /> | ||
**[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br /> | **[[3ceq]], [[3nf1]] – hKLC2 TPR domain<br /> | ||
| - | **[[3zfw]] - mKLC2 TPR domain + peptide<br /> | + | **[[3zfw]], [[5fjy]] - mKLC2 TPR domain + peptide<br /> |
| + | |||
| + | *Kinesin-3 motor domain | ||
| + | |||
| + | **[[4uxo]], [[4uxp]], [[4uxr]], [[4uxs]], [[4uxt]] - KIF + tubulin 1B, 2B chains + GDP + GTP – bovine – Cryo EM <br /> | ||
*Kinesin-5 motor domain | *Kinesin-5 motor domain | ||
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**[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br /> | **[[4aqv]], [[4aqw]] – hKIF11 (mutant) + tubulin + GDP + GTP + Mg – Cryo EM<br /> | ||
**[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br /> | **[[4ck5]], [[4ck6]], [[4ck7]] – hKIF11 (mutant) + tubulin + ADP + GDP + GTP + Mg – Cryo EM<br /> | ||
| + | **[[4pxt]], [[4pxu]] –DmKIF (mutant)<br /> | ||
*Kinesin-14 | *Kinesin-14 | ||
Revision as of 08:22, 29 June 2017
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3D Structures of Kinesin
Updated on 29-June-2017
References
- ↑ Hirokawa N, Noda Y, Tanaka Y, Niwa S. Kinesin superfamily motor proteins and intracellular transport. Nat Rev Mol Cell Biol. 2009 Oct;10(10):682-96. doi: 10.1038/nrm2774. PMID:19773780 doi:http://dx.doi.org/10.1038/nrm2774
- ↑ Ebbing B, Mann K, Starosta A, Jaud J, Schols L, Schule R, Woehlke G. Effect of spastic paraplegia mutations in KIF5A kinesin on transport activity. Hum Mol Genet. 2008 May 1;17(9):1245-52. doi: 10.1093/hmg/ddn014. Epub 2008 Jan, 18. PMID:18203753 doi:http://dx.doi.org/10.1093/hmg/ddn014
- ↑ Hirokawa N, Takemura R. Biochemical and molecular characterization of diseases linked to motor proteins. Trends Biochem Sci. 2003 Oct;28(10):558-65. PMID:14559185 doi:http://dx.doi.org/10.1016/j.tibs.2003.08.006
- ↑ Grosch M, Gruner B, Spranger S, Stutz AM, Rausch T, Korbel JO, Seelow D, Nurnberg P, Sticht H, Lausch E, Zabel B, Winterpacht A, Tagariello A. Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype. Matrix Biol. 2013 Oct-Nov;32(7-8):387-92. doi: 10.1016/j.matbio.2013.05.001. Epub, 2013 May 9. PMID:23665482 doi:http://dx.doi.org/10.1016/j.matbio.2013.05.001
- ↑ Nitta R, Okada Y, Hirokawa N. Structural model for strain-dependent microtubule activation of Mg-ADP release from kinesin. Nat Struct Mol Biol. 2008 Oct;15(10):1067-75. Epub 2008 Sep 21. PMID:18806800 doi:10.1038/nsmb.1487
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