1q0d
From Proteopedia
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'''Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the oxidized state''' | '''Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the oxidized state''' | ||
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[[Category: Yim, H S.]] | [[Category: Yim, H S.]] | ||
[[Category: Yim, Y I.]] | [[Category: Yim, Y I.]] | ||
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Revision as of 02:42, 3 May 2008
Crystal structure of Ni-containing superoxide dismutase with Ni-ligation corresponding to the oxidized state
Overview
Superoxide dismutases (SODs, EC 1.15.1.1) are ubiquitous enzymes that efficiently catalyze the dismutation of superoxide radical anions to protect biological molecules from oxidative damage. The crystal structure of nickel-containing SOD (NiSOD) from Streptomyces seoulensis was determined for the resting, x-ray-reduced, and thiosulfate-reduced enzyme state. NiSOD is a homohexamer consisting of four-helix-bundle subunits. The catalytic center resides in the N-terminal active-site loop, where a Ni(III) ion is coordinated by the amino group of His-1, the amide group of Cys-2, two thiolate groups of Cys-2 and Cys-6, and the imidazolate of His-1 as axial ligand that is lost in the chemically reduced state as well as after x-ray-induced reduction. This structure represents a third class of SODs concerning the catalytic metal species, subunit structure, and oligomeric organization. It adds a member to the small number of Ni-metalloenzymes and contributes with its Ni(III) active site to the general understanding of Ni-related biochemistry. NiSOD is shown to occur also in bacteria other than Streptomyces and is predicted to be present in some cyanobacteria.
About this Structure
1Q0D is a Single protein structure of sequence from Streptomyces seoulensis. The following page contains interesting information on the relation of 1Q0D with [Superoxide Dismutase]. Full crystallographic information is available from OCA.
Reference
Crystal structure of nickel-containing superoxide dismutase reveals another type of active site., Wuerges J, Lee JW, Yim YI, Yim HS, Kang SO, Djinovic Carugo K, Proc Natl Acad Sci U S A. 2004 Jun 8;101(23):8569-74. Epub 2004 Jun 1. PMID:15173586 Page seeded by OCA on Sat May 3 05:42:45 2008
