1q0e

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[[Image:1q0e.gif|left|200px]]
[[Image:1q0e.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1q0e |SIZE=350|CAPTION= <scene name='initialview01'>1q0e</scene>, resolution 1.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1q0e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1q0e| PDB=1q0e | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q0e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q0e OCA], [http://www.ebi.ac.uk/pdbsum/1q0e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q0e RCSB]</span>
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}}
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'''Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase'''
'''Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase'''
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[[Category: Hasnain, S S.]]
[[Category: Hasnain, S S.]]
[[Category: Hough, M A.]]
[[Category: Hough, M A.]]
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[[Category: atomic resolution]]
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[[Category: Atomic resolution]]
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[[Category: bovine]]
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[[Category: Bovine]]
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[[Category: copper]]
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[[Category: Copper]]
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[[Category: superoxide dismutase]]
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[[Category: Superoxide dismutase]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:42:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:07:04 2008''
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Revision as of 02:42, 3 May 2008

Image:1q0e.gif

Template:STRUCTURE 1q0e

Atomic resolution (1.15 ) crystal structure of bovine copper, zinc superoxide dismutase


Overview

Copper zinc superoxide dismutase (CuZnSOD) forms a crucial component of the cellular response to oxidative stress by catalyzing the dismutation of the superoxide radical to hydrogen peroxide and water. Mutations in human CuZnSOD are associated with the development of familial amyotrophic lateral sclerosis (motor neuron disease). We have determined the structure of fully reduced bovine CuZnSOD to 1.15 A, the only atomic resolution structure for an intact CuZnSOD and one of only a small number for metalloproteins. For the first time, both subunits have been captured with the three coordinate Cu(I) ligation required by the generally accepted catalytic mechanism, where dismutation of the superoxide radical occurs via reduction of Cu. Furthermore, the improved resolution compared to previous studies (to 1.65 A) has allowed a more detailed examination of the metal center environment and its associated water network in the active site channel, facilitating the analysis of potential proton transfer routes.

About this Structure

1Q0E is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of fully reduced bovine copper zinc superoxide dismutase at 1.15 A., Hough MA, Hasnain SS, Structure. 2003 Aug;11(8):937-46. PMID:12906825 Page seeded by OCA on Sat May 3 05:42:47 2008

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OCA

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