Ubiquitin conjugating enzyme

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Line 20: Line 20:
**[[2e2c]] – Ubc – ''Spisula solidissima'' <BR />
**[[2e2c]] – Ubc – ''Spisula solidissima'' <BR />
**[[1q34]] – CeUbc – ''Caenorhabidis elegans'' <BR />
**[[1q34]] – CeUbc – ''Caenorhabidis elegans'' <BR />
-
**[[2qcq]], [[1fzy]] – yUbc – yeast <BR />
 
**[[1jas]] – hUbc – human <BR />
**[[1jas]] – hUbc – human <BR />
**[[2fo3]] – Ubc – ''Plasmodium vivax'' <BR />
**[[2fo3]] – Ubc – ''Plasmodium vivax'' <BR />
Line 28: Line 27:
*Ubiquitin conjugating enzyme 1
*Ubiquitin conjugating enzyme 1
 +
**[[1fzy]] – yUbc – yeast <BR />
**[[1tte]] – yUbc (mutant) <BR />
**[[1tte]] – yUbc (mutant) <BR />
**[[2aak]] – AtUbc <BR />
**[[2aak]] – AtUbc <BR />
Line 38: Line 38:
**[[1z2u]] – CeUbc <BR />
**[[1z2u]] – CeUbc <BR />
**[[4r62]] – yUbc + ubiquitin carboxyl extension protein 80 <BR />
**[[4r62]] – yUbc + ubiquitin carboxyl extension protein 80 <BR />
 +
**[[5aie]] – yUbc + NOT4 <BR />
*Ubiquitin conjugating enzyme 4
*Ubiquitin conjugating enzyme 4
**[[1qcq]] – yUbc <BR />
**[[1qcq]] – yUbc <BR />
-
**[[4ii2]] – Ubc (mutant) + E1 + ATP – fission yeast<BR />
+
**[[4ii2]] – fyUbc (mutant) + E1 + ATP – fission yeast<BR />
**[[5aie]] – yUbc + NOT4 RING domain <BR />
**[[5aie]] – yUbc + NOT4 RING domain <BR />
- 
-
*Ubiquitin conjugating enzyme 5
 
- 
-
**[[2esk]], [[2clw]], [[3l1y]], [[3tgd]], [[2c4p]], [[1x23]] – hUbc <BR />
 
-
**[[2eso]], [[2esp]], [[2esq]] – hUbc (mutant)<BR />
 
-
**[[1w4u]] – hUbc - NMR<BR />
 
- 
-
*Ubiquitin conjugating enzyme 5 complexes
 
- 
-
**[[1ur6]] – hUbc + Cnot4 - NMR<BR />
 
-
**[[3eb6]] – Ubc + baculoviral IAP repeat-containing protein- frog<BR />
 
-
**[[4auq]] – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin<BR />
 
-
**[[3ptf]], [[4ddg]], [[4ddi]] – hUbc + ubiquitin<BR />
 
-
**[[2fuh]] – hUbc + ubiquitin - NMR<BR />
 
-
**[[3a33]], [[3ugb]] – hUbc (mutant) + ubiquitin<BR />
 
-
**[[3jvz]], [[3jw0]] – hUbc (mutant) + E3 NEDD4-2 + ubiquitin<BR />
 
-
**[[4ap4]] – hUbc + E3 Rnf4 + ubiquitin<BR />
 
-
**[[3oj4]] – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin<BR />
 
-
**[[4a49]] – hUbc + E3 Cbl <BR />
 
-
**[[4a4b]], [[4a4c]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
 
-
**[[3l1z]] – hUbc + ubiquitin conjugating factor<BR />
 
-
**[[3rpg]] – hUbc + E3 Ring2 + polycomb complex protein Bmi-1 <BR />
 
-
**[[3zni]] – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide <BR />
 
*Ubiquitin conjugating enzyme 6
*Ubiquitin conjugating enzyme 6
Line 82: Line 60:
**[[3sy2]] – hUbc + E3 Sopa <BR />
**[[3sy2]] – hUbc + E3 Sopa <BR />
**[[4q5e]], [[4q5h]] – hUbc (mutant) + ubiquitin + OspG<BR />
**[[4q5e]], [[4q5h]] – hUbc (mutant) + ubiquitin + OspG<BR />
 +
**[[6cp2]] – hUbc (mutant) + UBB + SidC<BR />
 +
**[[6djw]], [[6djx]] – hUbc (mutant) + ubiquitin + PARKIN<BR />
 +
**[[5tte]], [[5udh]] – hUbc (mutant) + ubiquitin + ARIH1<BR />
**[[5hpt]] – hUbc + ubiquitin + NEDD4-like E3 ubiquitin-protein<BR />
**[[5hpt]] – hUbc + ubiquitin + NEDD4-like E3 ubiquitin-protein<BR />
Line 100: Line 81:
**[[3o2u]] – yUbc <BR />
**[[3o2u]] – yUbc <BR />
 +
**[[2edi]] – hUbc 2 UQ-CON domain - NMR <BR />
 +
**[[1y8x]] – hUbc + E1 NEDD8 <BR />
**[[1tt5]] – hUbc + E1 Uba3, APPBP1 subunits <BR />
**[[1tt5]] – hUbc + E1 Uba3, APPBP1 subunits <BR />
**[[1y8x]] – hUbc + E1 NEDD8 <BR />
**[[1y8x]] – hUbc + E1 NEDD8 <BR />
Line 105: Line 88:
**[[3fn1]] – hUbc + E1 NEDD8-activating enzyme <BR />
**[[3fn1]] – hUbc + E1 NEDD8-activating enzyme <BR />
**[[3tdu]] – hUbc + cullin-1 + Dcn1-like protein <BR />
**[[3tdu]] – hUbc + cullin-1 + Dcn1-like protein <BR />
 +
**[[4p5o]] – hUbc + cullin-1 + Dcn1-like protein + Rbx1 + NEDD8<BR />
**[[4gao]] – hUbc + Dcn1-like protein <BR />
**[[4gao]] – hUbc + Dcn1-like protein <BR />
**[[3tdi]] – hUbc + defective in cullin neddylation protein <BR />
**[[3tdi]] – hUbc + defective in cullin neddylation protein <BR />
Line 111: Line 95:
**[[1jbb]] – yUbc <BR />
**[[1jbb]] – yUbc <BR />
 +
**[[4fh1]] – hUbc (mutant) <BR />
**[[1jat]] – yUbc/Mms2 <BR />
**[[1jat]] – yUbc/Mms2 <BR />
**[[1j74]] – hMms2 <BR />
**[[1j74]] – hMms2 <BR />
Line 116: Line 101:
**[[4onl]], [[4onm]], [[4onn]] – hUbc + Mms2 (mutant) <BR />
**[[4onl]], [[4onm]], [[4onn]] – hUbc + Mms2 (mutant) <BR />
**[[4nr3]], [[4nrg]], [[4nri]] – hUbc (mutant) + Mms2 <BR />
**[[4nr3]], [[4nrg]], [[4nri]] – hUbc (mutant) + Mms2 <BR />
-
**[[4fh1]] – hUbc (mutant) <BR />
+
**[[3von]] – hUbc + Otub1 + E2 variant <BR />
*Ubiquitin conjugating enzyme 13 complexes
*Ubiquitin conjugating enzyme 13 complexes
Line 136: Line 121:
**[[4ip3]], [[3w31]] – hUbc + Orf169b <BR />
**[[4ip3]], [[3w31]] – hUbc + Orf169b <BR />
**[[2oxq]] – Ubc + CHIP U-box - zebrafish<BR />
**[[2oxq]] – Ubc + CHIP U-box - zebrafish<BR />
 +
**[[5ojw]] – yUbc + Mms2 <BR />
*Ubiquitin conjugating enzyme 16 or Ubc W
*Ubiquitin conjugating enzyme 16 or Ubc W
Line 147: Line 133:
**[[2ybf]] – hUbc + Rad18<br />
**[[2ybf]] – hUbc + Rad18<br />
-
*Ubiquitin conjugating enzyme D
+
*Ubiquitin conjugating enzyme D1
 +
**[[2c4p]] – hUbc D1 <BR />
**[[2yho]] – hUbc D1 + E3 Mylip <BR />
**[[2yho]] – hUbc D1 + E3 Mylip <BR />
**[[5fer]] – hUbc D1 + ubiquitin carboxyl extension protein 80 + TRIM25 ring <BR />
**[[5fer]] – hUbc D1 + ubiquitin carboxyl extension protein 80 + TRIM25 ring <BR />
**[[4qpl]] – hUbc D1 + E3 ubiquitin-protein ligase RNF146<BR />
**[[4qpl]] – hUbc D1 + E3 ubiquitin-protein ligase RNF146<BR />
-
**[[4ldt]] – hUbc D2 + OTUB1 + ubiquitin <BR />
+
**[[3ptf]] – hUbc D1 + ubiquitin<BR />
 +
**[[4ap4]] – hUbc D1 + E3 ubiquitin-protein ligase RNF4 + ubiquitin<BR />
 +
**[[3oj4]] – hUbc D1 + tumor necrosis factor α-induced protein 3 + ubiquitin<BR />
 +
 
 +
*Ubiquitin conjugating enzyme D2
 +
 
 +
**[[2esk]], [[2clw]], [[3l1y]], [[3tgd]] – hUbc D2 <BR />
 +
**[[2eso]], [[2esp]], [[2esq]] – hUbc D2 (mutant)<BR />
 +
**[[1w4u]] – hUbc D2 - NMR<BR />
 +
**[[4ddg]], [[4ddi]] – hUbc D2 + ubiquitin<BR />
 +
**[[5ulf]], [[3a33]] – hUbc D2 (mutant) + ubiquitin <BR />
 +
**[[4ldt]] – hUbc D2 + Otub1 + ubiquitin <BR />
**[[5d1k]], [[5d1l]], [[5d1m]] – hUbc D2 + E3 ubiquitin-protein ligase RNF25<BR />
**[[5d1k]], [[5d1l]], [[5d1m]] – hUbc D2 + E3 ubiquitin-protein ligase RNF25<BR />
**[[5edv]] – hUbc D2 + ubiquitin + E3 ubiquitin-protein ligase RNF31<BR />
**[[5edv]] – hUbc D2 + ubiquitin + E3 ubiquitin-protein ligase RNF31<BR />
-
**[[4v3k]], [[4v3l]] – hUbc D2 + ubiquitin + E3 ubiquitin-protein ligase RNF38<BR />
+
**[[4a49]] – hUbc D2 + E3 ubiquitin-protein ligase CBL-B<BR />
-
**[[5d0k]], [[5d0m]] – hUbc D2 + ubiquitin + RING finger protein 165<BR />
+
**[[4v3k]], [[4v3l]], [[4a4b]], [[4a4c]] – hUbc D2 + ZAP peptide + E3 ubiquitin-protein ligase CBL-B<BR />
 +
**[[3zni]] – hUbc D2 + ubiquitin + E3 ubiquitin-protein ligase RNF38<BR />
 +
**[[5ulh]], [[5ulk]] – hUbc D2 (mutant) + ubiquitin + E3 ubiquitin-protein ligase RNF165<BR />
 +
**[[5mnj]] – hUbc D2 (mutant) + UBB + MDM2 + MDM4<BR />
 +
**[[5d0k]], [[5d0m]] – hUbc D2 + UBB + RING finger protein 165<BR />
 +
**[[4ldt]] – hUbc D2 (mutant) + ubiquitin + otub1 + ubiquitin aldehyde<BR />
**[[4wz3]] – hUbc D2 + E3 ubiquitin-protein ligase LubX<BR />
**[[4wz3]] – hUbc D2 + E3 ubiquitin-protein ligase LubX<BR />
-
**[[5egg]] – hUbc D3 <BR />
+
**[[5v2w]] – hUbc D2 (mutant) + ubiquitin + TRIM23<BR />
 +
**[[1ur6]] – hUbc D2 + Cnot4 - NMR<BR />
 +
**[[4auq]] – hUbc D2 (mutant) + baculoviral IAP repeat-containing protein + ubiquitin<BR />
 +
**[[3jvz]], [[3jw0]] – hUbc D2 (mutant) + E3 NEDD4-2 + ubiquitin<BR />
 +
**[[3eb6]] – fUbc D2 + baculoviral IAP repeat-containing protein- frog<BR />
 +
 
 +
*Ubiquitin conjugating enzyme D3
 +
 
 +
**[[5egg]], [[1x23]] – hUbc D3 <BR />
**[[5ifr]] – hUbc D3 + ubiquitin <BR />
**[[5ifr]] – hUbc D3 + ubiquitin <BR />
-
**[[4s3o]] – hUbc D3 + polycomb group ring finger protein + E3 ubiquitin-protein ligase RING2<BR />
+
**[[2fuh]] – hUbc D3 + ubiquitin - NMR<BR />
 +
**[[3ugb]] – hUbc D3 (mutant) + ubiquitin<BR />
 +
**[[3l1z]] – hUbc D3 + ubiquitin conjugating factor<BR />
 +
**[[4s3o]], [[3rpg]] – hUbc D3 + polycomb group ring finger protein + E3 ubiquitin-protein ligase RING2<BR />
**[[4bvu]] – hUbc D3 + OspG + ubiquitin <BR />
**[[4bvu]] – hUbc D3 + OspG + ubiquitin <BR />
Line 169: Line 183:
*Ubiquitin conjugating enzyme G2
*Ubiquitin conjugating enzyme G2
-
**[[3fsh]] – hUbc + autocrine motility factor receptor <BR />
+
**[[2cyx]] – hUbc<BR />
**[[2kly]] – hUbc - NMR<BR />
**[[2kly]] – hUbc - NMR<BR />
 +
**[[3fsh]] – hUbc + autocrine motility factor receptor <BR />
**[[2lxp]] – hUbc + AMFR peptide - NMR<BR />
**[[2lxp]] – hUbc + AMFR peptide - NMR<BR />
**[[3h8k]], [[4lad]] – hUbc + AMFR peptide <BR />
**[[3h8k]], [[4lad]] – hUbc + AMFR peptide <BR />

Revision as of 22:21, 2 October 2018

Structure of human ubiquitin conjugating enzyme E2 (green) complex with ubiquitin (deepskyblue) (PDB entry 3ptf)

Drag the structure with the mouse to rotate

3D Structures of ubiquitin conjugating enzyme

Updated on 02-October-2018

References

  1. ↑ Markson G, Kiel C, Hyde R, Brown S, Charalabous P, Bremm A, Semple J, Woodsmith J, Duley S, Salehi-Ashtiani K, Vidal M, Komander D, Serrano L, Lehner P, Sanderson CM. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Genome Res. 2009 Oct;19(10):1905-11. Epub 2009 Jun 23. PMID:19549727 doi:http://dx.doi.org/gr.093963.109
  2. ↑ Bosanac I, Phu L, Pan B, Zilberleyb I, Maurer B, Dixit VM, Hymowitz SG, Kirkpatrick DS. Modulation of K11-Linkage Formation by Variable Loop Residues within UbcH5A. J Mol Biol. 2011 May 6;408(3):420-31. Epub 2011 Mar 10. PMID:21396940 doi:10.1016/j.jmb.2011.03.011

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Michal Harel, Alexander Berchansky, David A Taves

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