1q22

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[[Image:1q22.gif|left|200px]]
[[Image:1q22.gif|left|200px]]
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{{Structure
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|PDB= 1q22 |SIZE=350|CAPTION= <scene name='initialview01'>1q22</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1q22", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A3P:ADENOSINE-3&#39;-5&#39;-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=AND:3-BETA-HYDROXY-5-ANDROSTEN-17-ONE'>AND</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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|ACTIVITY=
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|GENE= SULT2B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1q22| PDB=1q22 | SCENE= }}
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|RELATEDENTRY=[[1q1q|1Q1Q]], [[1q1z|1Q1Z]], [[1q20|1Q20]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q22 OCA], [http://www.ebi.ac.uk/pdbsum/1q22 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q22 RCSB]</span>
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}}
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'''Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP'''
'''Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP'''
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[[Category: Pedersen, L C.]]
[[Category: Pedersen, L C.]]
[[Category: Strott, C A.]]
[[Category: Strott, C A.]]
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[[Category: dhea]]
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[[Category: Dhea]]
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[[Category: pap]]
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[[Category: Pap]]
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[[Category: sulfotransferase]]
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[[Category: Sulfotransferase]]
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[[Category: sult2b1b]]
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[[Category: Sult2b1b]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:46:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:07:46 2008''
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Revision as of 02:46, 3 May 2008

Image:1q22.gif

Template:STRUCTURE 1q22

Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of DHEA and PAP


Overview

The gene for human hydroxysteroid sulfotransferase (SULT2B1) encodes two peptides, SULT2B1a and SULT2B1b, that differ only at their amino termini. SULT2B1b has a predilection for cholesterol but is also capable of sulfonating pregnenolone, whereas SULT2B1a preferentially sulfonates pregnenolone and only minimally sulfonates cholesterol. We have determined the crystal structure of SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate at 2.9 and 2.4 A, respectively, as well as SULT2B1b in the presence of the acceptor substrate pregnenolone at 2.3 A. These structures reveal a different catalytic binding orientation for the substrate from a previously determined structure of hydroxysteroid sulfotransferase (SULT2A1) binding dehydroepiandrosterone. In addition, the amino-terminal helix comprising residues Asp19 to Lys26, which determines the specificity difference between the SULT2B1 isoforms, becomes ordered upon pregnenolone binding, covering the substrate binding pocket.

About this Structure

1Q22 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cholesterol sulfotransferase (SULT2B1b) in the presence of pregnenolone and 3'-phosphoadenosine 5'-phosphate. Rationale for specificity differences between prototypical SULT2A1 and the SULT2BG1 isoforms., Lee KA, Fuda H, Lee YC, Negishi M, Strott CA, Pedersen LC, J Biol Chem. 2003 Nov 7;278(45):44593-9. Epub 2003 Aug 14. PMID:12923182 Page seeded by OCA on Sat May 3 05:46:23 2008

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