Uridine 5'-monophosphate synthase
From Proteopedia
(Difference between revisions)
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<StructureSection load='2qcd' size='340' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP [[2qcd]]' scene='' > | <StructureSection load='2qcd' size='340' side='right' caption='Human uridine 5-monophosphate synthase OPD subunit dimer complex with UMP [[2qcd]]' scene='' > | ||
== Function == | == Function == | ||
| - | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>. UMPS N-terminal domain is an '''orotate phosphoribosyl transferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) which decarboxylates OMP to form UMP. | + | '''Uridine 5’-monophosphate synthase''' (UMPS) is a bifunctional enzyme catalyzes the formation of uridine monophosphate (UMP)<ref>PMID:8631878</ref>. UMPS N-terminal domain is an '''orotate phosphoribosyl transferase''' (OPRT) subunit which catalyzes the addition of ribose-phosphate to orotate forming orotidine 5’-monophosphate (OMP). The C-terminal subunit is '''orotidine 5’-phosphate decarboxylase''' (OPD) which decarboxylates OMP to form UMP. A potent inhibitor of OPD is BMP – a barbituric acid derivative. |
== Disease == | == Disease == | ||
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**[[3gdk]] - yOPD – yeast<br /> | **[[3gdk]] - yOPD – yeast<br /> | ||
**[[1dqw]], [[3gdr]], [[3gdm]] – yOPD (mutant) <br /> | **[[1dqw]], [[3gdr]], [[3gdm]] – yOPD (mutant) <br /> | ||
| - | **[[2eaw]], [[2jgy]], [[2p1f]], [[2qcc]], [[2qce]] - hOPD – human | + | **[[2eaw]], [[2jgy]], [[2p1f]], [[2qcc]], [[2qce]] - hOPD – human<br /> |
| + | **[[4n2y]] – AfOPD – ''Archaeoglobus fulgidus''<br /> | ||
| + | **[[4lui]] – MjOPD – ''Methanocaldococcus jannaschii''<br /> | ||
| + | **[[4dbd]] – SsOPD – ''Sulfolobus solftaricus'' <br /> | ||
| + | **[[4df0]] – TnOPD – ''Thermoproteus neutrophilus'' <br /> | ||
| + | **[[3ve9]] – MsOPD – ''Metallosphaera sedula'' <br /> | ||
*Uridine 5’-monophosphate synthase OPD subunit complex | *Uridine 5’-monophosphate synthase OPD subunit complex | ||
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**[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br /> | **[[3mi2]], [[4hib]], [[4hkp]] - hOPD + inhibitor<br /> | ||
**[[3ex1]] - hOPD + UMP derivative + UMP<br /> | **[[3ex1]] - hOPD + UMP derivative + UMP<br /> | ||
| - | **[[2qcl]] - yOPD (mutant) + OMP | + | **[[2qcl]] - yOPD (mutant) + OMP <br /> |
| + | **[[4lw7]] – MtOPD + BMP – ''Methanothermobacter thermautotrophicus''<br /> | ||
| + | **[[4lc6]], [[4lc8]], [[4fx8]], [[4gc4]], [[4fx6]], [[4fxr]], [[3v1p]] – MtOPD (mutant) + BMP <br /> | ||
| + | **[[4o8r]], [[4o11]], [[4nx5]], [[4nt0]], [[4nuw]], [[3wjw]], [[3wjx]], [[3wjy]], [[3wjz]], [[3w07]] - MtOPD + UMP derivative<br /> | ||
| + | **[[3wk0]], [[3wk1]], [[3wk2]], [[3wk3]] - MtOPD + OMP derivative<br /> | ||
| + | **[[4muz]] – AfOPD + BMP <br /> | ||
| + | **[[4luj]] – MjOPD + BMP <br /> | ||
| + | **[[4df1]] – TnOPD + BMP <br /> | ||
| + | **[[4dbe]] – SsOPD + BMP <br /> | ||
| + | **[[3ve7]] – MsOPD + BMP <br /> | ||
*Uridine 5’-monophosphate synthase OPRT subunit complex | *Uridine 5’-monophosphate synthase OPRT subunit complex | ||
| - | **[[2wns]] - hOPRT + OMP | + | **[[2wns]] - hOPRT + OMP<br /> |
| + | **[[4wml]] – yOPRT + phosphoribosyl pyrophosphate<br /> | ||
| + | **[[1lh0]], [[1opr]] – StOPRT + MgPRPP + orotate – ''Salmonella typhimurium''<br /> | ||
| + | |||
}} | }} | ||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 10:51, 8 December 2016
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3D structures of uridine 5'-monophosphate synthase
Updated on 08-December-2016
References
- ↑ Yablonski MJ, Pasek DA, Han BD, Jones ME, Traut TW. Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase. J Biol Chem. 1996 May 3;271(18):10704-8. PMID:8631878
- ↑ Grohmann K, Lauffer H, Lauenstein P, Hoffmann GF, Seidlitz G. Hereditary orotic aciduria with epilepsy and without megaloblastic anemia. Neuropediatrics. 2015 Apr;46(2):123-5. doi: 10.1055/s-0035-1547341. Epub 2015 Mar, 10. PMID:25757096 doi:http://dx.doi.org/10.1055/s-0035-1547341
- ↑ Schwenger B, Schober S, Simon D. DUMPS cattle carry a point mutation in the uridine monophosphate synthase gene. Genomics. 1993 Apr;16(1):241-4. PMID:8486364 doi:http://dx.doi.org/10.1006/geno.1993.1165
- ↑ Wittmann JG, Heinrich D, Gasow K, Frey A, Diederichsen U, Rudolph MG. Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design. Structure. 2008 Jan;16(1):82-92. PMID:18184586 doi:http://dx.doi.org/10.1016/j.str.2007.10.020
